CAS 117830-79-2|Enterostatin human
Introduction：Basic information about CAS 117830-79-2|Enterostatin human, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Enterostatin human | ||
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| CAS Number | 117830-79-2 | Molecular Weight | 496.56100 |
| Density | 1.54g/cm3 | Boiling Point | / |
| Molecular Formula | C21H36N8O6 | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | (2S)-2-[[(2S)-1-[2-[[(2S)-1-[(2S)-2-aminopropanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid |
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| Synonym | More Synonyms |
Enterostatin human BiologicalActivity
| Description | Enterostatin, human, mouse, rat is a pentapeptide that reduces fat intake. |
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| Related Catalog | PeptidesResearch Areas >>Metabolic DiseaseNatural Products >>Others |
| Target | Human Endogenous Metabolite |
| In Vitro | In the perfused ratpancreas, Enterostatin, at 100 mM, inhibits the insulin response to 9 mM glucose (by 70%), 0.1 mM tolbutamide (by 40%), and 5 mM arginine (by 70%)[1]. |
| In Vivo | Chronically, enterostatin reduces fat intake, bodyweight, and body fat. This response may involve multiple metabolic effects of enterostatin, which include a reduction of insulin secretion, an increase in sympathetic drive to brown adipose tissue, and the stimulation of adrenal corticosteroid secretion[2]. Enterostatin enhances memory consolidation after central or oral administration at a dose of 10 nmol/mouse or 300 mg/kg, respectively, in a step-through type passive avoidance test in mice[3]. A dose of 38 nmol of enterostatin gives a significant inhibition of high-fat food intake, while at a higher dose of 76 nmol the inhibiting effect is lost. During the first hour, after injection of enterostatin, there is even a slight increase in food intake[4]. |
| References | [1]. Silvestre RA, et al. Effect of enterostatin on insulin, glucagon, and somatostatin secretion in the perfused rat pancreas. Diabetes. 1996 Sep;45(9):1157-60. [2]. Erlanson-Albertsson C, et al. Enterostatin--a peptide regulating fat intake. Obes Res. 1997 Jul;5(4):360-72. [3]. Ohinata K, et al. Enterostatin (APGPR) enhances memory consolidation in mice. Peptides. 2007 Mar;28(3):719-21. [4]. Sörhede M, et al. Enterostatin: a gut-brain peptide regulating fat intake in rat. J Physiol Paris. 1993;87(4):273-5. |
Chemical & Physical Properties
| Density | 1.54g/cm3 |
|---|---|
| Molecular Formula | C21H36N8O6 |
| Molecular Weight | 496.56100 |
| Exact Mass | 496.27600 |
| PSA | 224.04000 |
| Index of Refraction | 1.681 |
| InChIKey | ITZMJCSORYKOSI-AJNGGQMLSA-N |
| SMILES | CC(N)C(=O)N1CCCC1C(=O)NCC(=O)N1CCCC1C(=O)NC(CCCN=C(N)N)C(=O)O |
| Storage condition | -20°C |
Safety Information
| Hazard Codes | Xi |
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Synonyms
| CLAP |
| H-Ala-Pro-Gly-Pro-Arg-OH |
| Enterostatin human |
| APGPR |
| APGPR Enterostatin |
| Ala-pro-gly-pro-arg |
| Procolipase activation peptide |
| ALA-PRO-GLY-PRO-ARG |
| Enterostatin, human, mouse, rat |
