Introduction：Basic information about CAS 117857-45-1|Loreclezole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Loreclezole |
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| CAS Number | 117857-45-1 | Molecular Weight | 274.53 |
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| Density | 1.48g/cm3 | Boiling Point | 418.7ºC at 760mmHg |
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| Molecular Formula | C10H6Cl3N3 | Melting Point | / |
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| MSDS | / | Flash Point | 207ºC |
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Names
| Name | Loreclezole hydrochloride,(Z)-1-[2-Chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-1,2,4-triazolehydrochloride |
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| Synonym | More Synonyms |
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Loreclezole BiologicalActivity
| Description | Loreclezole, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors[1][2]. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>GABA Receptor |
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| Target | GABAA receptor[1]. |
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| References | [1]. Wingrove PB, et al. The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit. Proc Natl Acad Sci U S A. 1994 May 10;91(10):4569-73. [2]. Sanna E, et al. Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit. Neuropharmacology. 1996;35(12):1753-60. |
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Chemical & Physical Properties
| Density | 1.48g/cm3 |
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| Boiling Point | 418.7ºC at 760mmHg |
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| Molecular Formula | C10H6Cl3N3 |
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| Molecular Weight | 274.53 |
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| Flash Point | 207ºC |
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| Exact Mass | 272.96300 |
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| PSA | 30.71000 |
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| LogP | 3.77930 |
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| Vapour Pressure | 3.23E-07mmHg at 25°C |
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| Index of Refraction | 1.65 |
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| InChIKey | XGLHZTBDUXXHOM-WMZJFQQLSA-N |
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| SMILES | ClC(=Cn1cncn1)c1ccc(Cl)cc1Cl |
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| Storage condition | 2-8℃ |
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Safety Information
Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Sodium phosphate monobasic |
| Loreclezole |
| LoreclezoleHCl |
