Introduction：Basic information about CAS 121288-39-9|Loxoribine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Loxoribine |
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| CAS Number | 121288-39-9 | Molecular Weight | 339.30400 |
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| Density | 1.92g/cm3 | Boiling Point | 591.8ºC at 760mmHg |
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| Molecular Formula | C13H17N5O6 | Melting Point | 227-230ºC(lit.) |
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| MSDS | / | Flash Point | 311.7ºC |
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Names
| Name | 7-allyl-8-oxoguanosine |
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| Synonym | More Synonyms |
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Loxoribine BiologicalActivity
| Description | Loxoribine (7-Allyl-8-oxoguanosine) is a guanosine analog with anti-viral and anti-tumor activities. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist[1][2][3]. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Toll-like Receptor (TLR)Research Areas >>CancerResearch Areas >>Infection |
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| Target | TLR7[1] |
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| In Vitro | Loxoribine induces maturation of human monocyte-derived dendritic cells DCs and stimulates their Th-1- and Th-17-polarizing capability[2]. Loxoribine (250 μM; 48 hours) stimulates maturation of MoDCs as shown by up-regulation of CD80, CD83, CD40, CD54 and CCR7[2]. loxoribine activates cells of the innate immune system selectively via the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway[1]. |
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| In Vivo | Loxoribine (2 mg; s.c.or i.v.) activates murine natural killer (NK) cells in vivo[3]. Animal Model: 8-12 weeks male CBA/J mice[3] Dosage: 2 mg Administration: Subcutaneous or intravenous injection Result: activates murine natural killer (NK) cells in vivo. |
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| References | [1]. Heil F, et al. The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur J Immunol. 2003 Nov;33(11):2987-97. [2]. Dzopalic T, et al. Loxoribine, a selective Toll-like receptor 7 agonist, induces maturation of human monocyte-derived dendritic cells and stimulates their Th-1- and Th-17-polarizing capability. Int Immunopharmacol. 2010 Nov;10(11):1428-33. [3]. Pope BL, et al. In vivo enhancement of murine natural killer cell activity by 7-allyl-8-oxoguanosine (loxoribine). Int J Immunopharmacol. 1992 Nov;14(8):1375-82. |
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Chemical & Physical Properties
| Density | 1.92g/cm3 |
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| Boiling Point | 591.8ºC at 760mmHg |
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| Melting Point | 227-230ºC(lit.) |
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| Molecular Formula | C13H17N5O6 |
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| Molecular Weight | 339.30400 |
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| Flash Point | 311.7ºC |
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| Exact Mass | 339.11800 |
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| PSA | 168.62000 |
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| Vapour Pressure | 1.81E-16mmHg at 25°C |
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| Index of Refraction | 1.812 |
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| Storage condition | Desiccate at +4°C |
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Safety Information
Synonyms
| 7-ALLYL-7 8-DIHYDRO-8-OXOGUANOSINE 95 |
| 7-allyl-8-oxo-G |
| Loxoribine |
| 7-Allyl-7,8-dihydro-8-oxoguanosine |
| MFCD00867591 |
