CAS 170663-33-9|α-Conotoxin EI

Introduction：Basic information about CAS 170663-33-9|α-Conotoxin EI, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. α-Conotoxin EI BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	α-Conotoxin EI
CAS Number	170663-33-9	Molecular Weight	2093.37000
Density	/	Boiling Point	/
Molecular Formula	C₈₃H₁₂₅N₂₇O₂₇S₅	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	α-Conotoxin EI
Synonym	More Synonyms

α-Conotoxin EI BiologicalActivity

Description	α-Conotoxin EI is a selective nicotinic acetylcholine α1β1γδ receptor (nAChR) antagonist (IC50=187 nM) and an α3β4 receptor inhibitor. α-Conotoxin EI can block muscle and ganglionic receptors[1][2][3].
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>nAChRSignaling Pathways >>Neuronal Signaling >>nAChRResearch Areas >>Neurological Disease
Target	IC50: 187 nM (nicotinic acetylcholine α1β1γδ receptor)[3]
In Vitro	α-Conotoxin EI (10 µM) blocks muscle and ganglionic receptors, but less potent for the central nevous system receptor[3]. α-Conotoxin EI (10 µM) blocks the α1β1γδ receptors with a τon of 4.9 s, and blocks the α3β4 receptor with a τon of 11 s[3].
In Vivo	α-Conotoxin EI (intraperitoneal injection) into mice induces muscular weakness, followed by flaccid paralysis and ultimately death[1].

Chemical & Physical Properties

Molecular Formula	C₈₃H₁₂₅N₂₇O₂₇S₅
Molecular Weight	2093.37000
Exact Mass	2091.78000
PSA	1002.01000
InChIKey	ZUOKYBVKCMQKIN-UHFFFAOYSA-N
SMILES	CCC(C)C1NC(=O)C(CCC(N)=O)NC(=O)C2CCCN2C(=O)C(CC(N)=O)NC(=O)C(CO)NC(=O)C(CCSC)NC(=O)C(CC(N)=O)NC(=O)C2CSSCC(NC(=O)C3CC(O)CN3C(=O)C(CC(=O)O)NC(=O)C(N)CCCNC(=N)N)C(=O)NC(CSSCC(C(N)=O)NC1=O)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(Cc1c[nH]cn1)C(=O)N1CCCC1C(=O)NC(C(C)O)C(=O)N2

Synonyms

ARG-ASP-HYP-CYS-CYS-TYR-HIS-PRO-THR-CYS-ASN-MET-SER-ASN-PRO-GLN-ILE-CYS-NH2

A-CONOTOXIN EL

ARG-ASP-HYP-CYS-CYS-TYR-HIS-PRO-THR-CYS-ASN-MET-SER-ASN-PRO-GLN-ILE-CYS

RDHYPCCYHPTCNMSNPQIC-NH2

H-ARG-ASP-HYP-CYS-CYS-TYR-HIS-PRO-THR-CYS-ASN-MET-SER-ASN-PRO-GLN-ILE-CYS-NH2

a-Conotoxin El,Conus ermineus

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