Introduction：Basic information about CAS 170912-52-4|Donitriptan, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Donitriptan |
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| CAS Number | 170912-52-4 | Molecular Weight | 403.47700 |
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| Density | 1.32g/cm3 | Boiling Point | 727.1ºC at 760mmHg |
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| Molecular Formula | C23H25N5O2 | Melting Point | / |
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| MSDS | / | Flash Point | 393.6ºC |
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Names
| Name | 4-[4-[2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]acetyl]piperazin-1-yl]benzonitrile |
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| Synonym | More Synonyms |
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Donitriptan BiologicalActivity
| Description | Donitriptan is a potent, high efficacy agonist at 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively[1]. |
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| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor |
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| Target | 5-HT1B Receptor:9.4 (pKi) 5-HT1D Receptor:9.3 (pKi) |
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| References | [1]. Muñoz-Islas E, et al. Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors. Br J Pharmacol. 2006 Sep;149(1):82-91. |
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Chemical & Physical Properties
| Density | 1.32g/cm3 |
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| Boiling Point | 727.1ºC at 760mmHg |
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| Molecular Formula | C23H25N5O2 |
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| Molecular Weight | 403.47700 |
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| Flash Point | 393.6ºC |
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| Exact Mass | 403.20100 |
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| PSA | 98.38000 |
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| LogP | 2.97158 |
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| Vapour Pressure | 5.34E-21mmHg at 25°C |
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| Index of Refraction | 1.688 |
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| InChIKey | SOHCKWZVTCTQBG-UHFFFAOYSA-N |
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| SMILES | N#Cc1ccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)cc1 |
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Synonyms
