Introduction：Basic information about CAS 172895-15-7|ly 272015 hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ly 272015 hydrochloride |
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| CAS Number | 172895-15-7 | Molecular Weight | 372.88800 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C21H25ClN2O2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 1-[(3,4-dimethoxyphenyl)methyl]-6-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole |
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| Synonym | More Synonyms |
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ly 272015 hydrochloride BiologicalActivity
| Description | LY-272015 hydrochloride is an orally active, specific 5-HT2B receptor antagonist. LY-272015 hydrochloride completely inhibits the phosphorylation of ERK2 induced by 5-HT or BW723C86. LY-272015 hydrochloride is antihypertensive in Deoxycorticosterone Acetate (DOCA)-salt-hypertensive rats[1][2]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor |
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| Target | 5-HT2B Receptor |
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| References | [1]. S W Watts, et al. 5-HT2B-receptor antagonist LY-272015 is antihypertensive in DOCA-salt-hypertensive rats. Am J Physiol. 1999 Mar;276(3):H944-52. [2]. Kota Naito, et al. Signal Transduction Mechanism for Serotonin 5-HT2B Receptor-Mediated DNA Synthesis and Proliferation in Primary Cultures of Adult Rat Hepatocytes. Biol Pharm Bull. 2016;39(1):121-9. |
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Chemical & Physical Properties
| Molecular Formula | C21H25ClN2O2 |
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| Molecular Weight | 372.88800 |
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| Exact Mass | 372.16000 |
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| PSA | 46.28000 |
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| LogP | 5.05380 |
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| InChIKey | BKAZOTIBKRWLQA-UHFFFAOYSA-N |
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| SMILES | COc1ccc(CC2NCCc3c2[nH]c2ccc(C)cc32)cc1OC.Cl |
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| Storage condition | Store at +4°C |
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Synonyms
