Introduction：Basic information about CAS 773888-45-2|Biotin alkyne, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Biotin alkyne |
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| CAS Number | 773888-45-2 | Molecular Weight | 281.37400 |
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| Density | 1.185±0.06 g/cm3(Predicted) | Boiling Point | 614.8±50.0 °C(Predicted) |
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| Molecular Formula | C13H19N3O2S | Melting Point | 169-170 °C |
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| MSDS | / | Flash Point | / |
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Names
| Name | N-(Prop-2-ynyl)biotinamide |
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| Synonym | More Synonyms |
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Biotin alkyne BiologicalActivity
| Description | Biotin alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | PEGs |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| References | [1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1014. |
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Chemical & Physical Properties
| Density | 1.185±0.06 g/cm3(Predicted) |
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| Boiling Point | 614.8±50.0 °C(Predicted) |
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| Melting Point | 169-170 °C |
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| Molecular Formula | C13H19N3O2S |
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| Molecular Weight | 281.37400 |
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| Exact Mass | 281.12000 |
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| PSA | 95.53000 |
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| LogP | 1.51010 |
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| InChIKey | JJXUHRONZVELPY-NHCYSSNCSA-N |
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| SMILES | C#CCNC(=O)CCCCC1SCC2NC(=O)NC21 |
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Safety Information
Synonyms
| Biotin propargylamide, 3-(D-Biotinylamido)-1-propyne, Prop-2-ynylamide biotin |
| 5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(prop-2-ynyl)pentanamide |
