Introduction：Basic information about CAS 79103-90-5|Polygalasaponin XXXI, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Polygalasaponin XXXI |
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| CAS Number | 79103-90-5 | Molecular Weight | 1589.670 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C75H112O36 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | onjisaponin F |
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| Synonym | More Synonyms |
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Polygalasaponin XXXI BiologicalActivity
| Description | Polygalasaponin XXXI (Onjisaponin F) is an effective adjuvant for intranasal administration of influenza Influenza hemagglutinin (HA) vaccine to protect influenza virus infection[1]. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>Influenza VirusResearch Areas >>Infection |
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| In Vitro | Polygalasaponin XXXI (Onjisaponin F) also enhances anti-HA IgA and IgG Ab titers in the nasal wash, whereas Onjisaponins E and G enhances only anti-HA IgA Ab titer significantly. Polygalasaponin XXXI can induce protective immunity against intranasal infection by influenza virus[1]. Polygalasaponin XXXI (Onjisaponin F) (1 or 10 µg/mL) also induces ChAT mRNA level in rat basal forebrain cells[2]. |
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| In Vivo | Intranasal vaccination with Polygalasaponin XXXI (Onjisaponin F) inhibits proliferation of mouse adapted influenza virus A/PR/8/34 in bronchoalveolar lavages of infected mice[1]. |
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| References | [1]. T Nagai, et al. Onjisaponins, From the Root of Polygala Tenuifolia Willdenow, as Effective Adjuvants for Nasal Influenza and Diphtheria-Pertussis-Tetanus Vaccines. Vaccine. 2001 Sep 14;19(32):4824-34. [2]. T Yabe, et al. Induction of NGF Synthesis in Astrocytes by Onjisaponins of Polygala Tenuifolia, Constituents of Kampo (Japanese Herbal) Medicine, Ninjin-yoei-to. Phytomedicine. 2003 Mar;10(2-3):106-14. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Molecular Formula | C75H112O36 |
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| Molecular Weight | 1589.670 |
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| Exact Mass | 1588.693359 |
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| PSA | 542.80000 |
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| LogP | 4.95 |
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| Index of Refraction | 1.651 |
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| InChIKey | HDLNHPZHTNFCNP-SDNWHVSQSA-N |
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| SMILES | COc1cc(C=CC(=O)OC2C(C)OC(OC(=O)C34CCC(C)(C)CC3C3=CCC5C6(C)CC(O)C(OC7OC(CO)C(O)C(O)C7O)C(C)(C(=O)O)C6CCC5(C)C3(CO)CC4)C(OC3OC(C)C(OC4OCC(O)C(OC5OCC(O)C(O)C5O)C4O)C(OC4OCC(O)(CO)C4O)C3O)C2O)cc(OC)c1OC |
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Synonyms
| Polygalasaponin XXXI |
| β-D-Galactopyranose, O-α-L-arabinopyranosyl-(1->3)-O-α-D-xylopyranosyl-(1->4)-O-6-deoxy-3-O-[(2S,3R,4R)-tetrahydro-3,4-dihydroxy-4-(hydroxymethyl)-2-furanyl]-α-L-mannopyranosyl-(1->2)-6 -deoxy-1-O-[(2β,3β)-3-(β-D-glucopyranosyloxy)-2,24,27-trihydroxy-24,28-dioxoolean-12-en-28-yl]-4-O-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]- |
| α-L-Arabinopyranosyl-(1->3)-α-D-xylopyranosyl-(1->4)-6-deoxy-3-O-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydro-2-furanyl]-α-L-mannopyranosyl-(1->2)-6-deoxy-1-O-[(2β,3β)-3-(be ta-D-glucopyranosyloxy)-2,24,27-trihydroxy-24,28-dioxoolean-12-en-28-yl]-4-O-[(2E)-3-(3,4,5-trimethoxyphenyl)-2-propenoyl]-β-D-galactopyranose |
