Introduction：Basic information about CAS 64887-70-3|(Nle4)-α-MSH, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (Nle4)-α-MSH |
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| CAS Number | 64887-70-3 | Molecular Weight | 1646.845 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C78H111N21O19 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 4-L-Norleucine-alpha-Melanotropin |
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| Synonym | More Synonyms |
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(Nle4)-α-MSH BiologicalActivity
| Description | (Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment[1]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>GPCR/G Protein >>Melanocortin Receptor |
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| Target | tyrosinase; melanoma adenylate cyclase[1] |
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| In Vitro | (Nle4)-α-MSH shows a better bioactivity than α-MSH in frog skin bioassay, activation of mouse melanoma adenylate cyclase, and stimulation of mouse melanoma cell tyrosinase activity[1]. (Nle4)-α-MSH (0.1 nM; 0.5, 4, 8 h) stimulates tyrosinase activity in melanoma cells (NCTC 3960)[1]. (Nle4)-α-MSH (0.1 nM; 1-4 h) increases biological activity of melanotropins, indicating darkening response of frog skins[1]. (Nle4)-α-MSH (0.1 μg) also activates mouse melanoma adenylate cyclase[1]. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Molecular Formula | C78H111N21O19 |
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| Molecular Weight | 1646.845 |
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| Exact Mass | 1645.836548 |
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| PSA | 642.98000 |
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| LogP | -0.80 |
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| Index of Refraction | 1.674 |
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| InChIKey | UAHFGYDRQSXQEB-PWPYQVNISA-N |
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| SMILES | CCCCC(NC(=O)C(CO)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(C)=O)C(=O)NC(CCC(=O)O)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCC(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(C(N)=O)C(C)C |
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Synonyms
| L-Valinamide, N-acetyl-L-seryl-L-tyrosyl-L-seryl-L-norleucyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl- |
| (4-Norleucine)Alpha-Msh |
| 4-Nle-Alpha-Msh |
| N-Acetyl-L-seryl-L-tyrosyl-L-seryl-L-norleucyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valinamide |
| Msh, 4-Nle-Alpha- |
| N-acetyl-L-seryl-L-tyrosyl-L-seryl-L-norleucyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-N-(diaminomethylidene)-L-ornithyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valinamide |
