Introduction：Basic information about CAS 184865-04-1|Amyloid β-Protein (29-40), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Amyloid β-Protein (29-40) |
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| CAS Number | 184865-04-1 | Molecular Weight | 1085.36000 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C49H88N12O13S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | amyloid β-protein(30-40) |
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| Synonym | More Synonyms |
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Amyloid β-Protein (29-40) BiologicalActivity
| Description | β-Amyloid (29-40) is a fragment of Amyloid-β peptide. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>Amyloid-βPeptidesResearch Areas >>Neurological Disease |
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| Target | Amyloid-β[1] |
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| In Vitro | β-Amyloid (29-40) is a fragment of Amyloid-β peptide, unsoluble in water, acetonitrile or in a mixture of both in different ratios. Cationic arginine residues is introduced at β-Amyloid (29-40) C-terminus to solubilize β-Amyloid (29-40) and introduce cationicity in this Aβ stretch to enable it to interact with the negatively charged membrane of bacteria. β-Amyloid (29-40) variants shows antimicrobial effect[1]. Single chain variable fragments (scFv's) binds the 17-28 region of Abeta and effectively inhibits in vitro aggregation of Abeta, but binding the carboxyl-terminal region of β-Amyloid (29-40) does not inhibit aggregation[2]. |
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| References | [1]. Harioudh MK, et al. A short non-cytotoxic antimicrobial peptide designed from Aβ29-40 adopts a nanostructure and shows in vivo anti-endotoxin activity. Chem Commun (Camb). 2017 Dec 5;53(97):13079-13082. [2]. Liu R, et al. Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent abeta-induced neurotoxicity. Biochemistry. 2004 Jun 8;43(22):6959-67. |
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Chemical & Physical Properties
| Molecular Formula | C49H88N12O13S |
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| Molecular Weight | 1085.36000 |
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| Exact Mass | 1084.63000 |
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| PSA | 408.72000 |
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| LogP | 3.13620 |
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| InChIKey | CBRNMAKKYFYZMI-UHFFFAOYSA-N |
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| SMILES | CCC(C)C(NC(=O)C(C)NC(=O)CN)C(=O)NC(C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCSC)C(=O)NC(C(=O)NCC(=O)NCC(=O)NC(C(=O)NC(C(=O)O)C(C)C)C(C)C)C(C)C)C(C)CC |
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| Storage condition | 2-8℃ |
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Synonyms
| Aβ(30-40) |
| β-Amyloid (29-40) |
