CAS 18887-19-9|METHYL TANSHINONATE

Introduction：Basic information about CAS 18887-19-9|METHYL TANSHINONATE, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. METHYL TANSHINONATE BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	METHYL TANSHINONATE
CAS Number	18887-19-9	Molecular Weight	338.35
Density	1.296±0.06 g/cm3	Boiling Point	523.4±50.0 °C at 760 mmHg
Molecular Formula	C₂₀H₁₈O₅	Melting Point	175-176 °C
MSDS	/	Flash Point	/

Names

Name	methyl (-)-(S)-tanshinonate
Synonym	More Synonyms

METHYL TANSHINONATE BiologicalActivity

Description	Methyl tanshinonate is a tanshinone, that can be isolated from Salvia miltiorrhiza (S. miltiorrhiza) Bunge (Lamiaceae). Methyl tanshinonate is a potent inhibitor of Mpro enzyme in SARS-CoV (IC50 = 21.1 µM). Methyl tanshinonate can be used for diabetes and SARS-CoV research[1][2][3].
Related Catalog	Research Areas >>InfectionSignaling Pathways >>Anti-infection >>SARS-CoVResearch Areas >>Metabolic Disease
References	[1]. Kim DH, et al. Characterization of the inhibitory activity of natural tanshinones from Salvia miltiorrhiza roots on protein tyrosine phosphatase 1B. Chem Biol Interact. 2017 Dec 25;278:65-73. [2]. Ni L, et al. Qualitative analysis of the roots of Salvia miltiorrhiza and Salvia yunnanensis based on NIR, UHPLC and LC-MS-MS. J Pharm Biomed Anal. 2019 Jun 5;170:295-304. [3]. Diniz LRL, et al. Bioactive Terpenes and Their Derivatives as Potential SARS-CoV-2 Proteases Inhibitors from Molecular Modeling Studies. Biomolecules. 2021 Jan 7;11(1):74.

Description

Methyl tanshinonate is a tanshinone, that can be isolated from Salvia miltiorrhiza (S. miltiorrhiza) Bunge (Lamiaceae). Methyl tanshinonate is a potent inhibitor of Mpro enzyme in SARS-CoV (IC50 = 21.1 µM). Methyl tanshinonate can be used for diabetes and SARS-CoV research[1][2][3].

Related Catalog

Research Areas >>InfectionSignaling Pathways >>Anti-infection >>SARS-CoVResearch Areas >>Metabolic Disease

References

[1]. Kim DH, et al. Characterization of the inhibitory activity of natural tanshinones from Salvia miltiorrhiza roots on protein tyrosine phosphatase 1B. Chem Biol Interact. 2017 Dec 25;278:65-73.

[2]. Ni L, et al. Qualitative analysis of the roots of Salvia miltiorrhiza and Salvia yunnanensis based on NIR, UHPLC and LC-MS-MS. J Pharm Biomed Anal. 2019 Jun 5;170:295-304.

[3]. Diniz LRL, et al. Bioactive Terpenes and Their Derivatives as Potential SARS-CoV-2 Proteases Inhibitors from Molecular Modeling Studies. Biomolecules. 2021 Jan 7;11(1):74.

Chemical & Physical Properties

Density	1.296±0.06 g/cm3
Boiling Point	523.4±50.0 °C at 760 mmHg
Melting Point	175-176 °C
Molecular Formula	C₂₀H₁₈O₅
Molecular Weight	338.35
Exact Mass	338.11500
PSA	73.58000
LogP	3.40100
InChIKey	YFDKIHAZVQFLRC-FQEVSTJZSA-N
SMILES	COC(=O)C1(C)CCCc2c1ccc1c2C(=O)C(=O)c2c(C)coc2-1

Synonyms

(S)-1,6-Dimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydro-phenanthro[1,2-b]furan-6-carboxylic acid methyl ester

methyl tanshinonate

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