Introduction：Basic information about CAS 475150-69-7|BAN ORL 24, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | BAN ORL 24 |
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| CAS Number | 475150-69-7 | Molecular Weight | 433.59 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C27H35N3O2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 1-Benzyl-N-[3-(1'H,3H-spiro[2-benzofuran-1,4'-piperidin]-1'-yl)propyl]-D-prolinamide dihydrochloride |
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| Synonym | More Synonyms |
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BAN ORL 24 BiologicalActivity
| Description | BAN ORL 24 free base is a nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) antagonist. BAN ORL 24 free base has antagonistic effect for nociceptin (NOP) receptor with KI value of 0.24 nM in CHO cell. BAN ORL 24 free base can be used for the research of cancer and analgesic[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>GPCR/G Protein >>Opioid ReceptorSignaling Pathways >>Neuronal Signaling >>Opioid Receptor |
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| References | [1]. Tao Hou, et al. Label-free cell phenotypic study of opioid receptors and discovery of novel mu opioid ligands from natural products. J Ethnopharmacol [2]. Chao, et al. BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine. Neuropharmacology 166, 107678 (2020). [3]. Fischetti et al (2009) Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist compound 24. Eur.J.Pharmacol. 614 50. |
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Chemical & Physical Properties
| Molecular Formula | C27H35N3O2 |
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| Molecular Weight | 433.59 |
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| Exact Mass | 505.226288 |
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| InChIKey | MAKMQGKJURAJEN-RUZDIDTESA-N |
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| SMILES | O=C(NCCCN1CCC2(CC1)OCc1ccccc12)C1CCCN1Cc1ccccc1 |
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Synonyms
| 2-Pyrrolidinecarboxamide, 1-(phenylmethyl)-N-(3-spiro[isobenzofuran-1(3H),4'-piperidin]-1'-ylpropyl)-, (2R)-, hydrochloride (1:2) |
| 1-Benzyl-N-[3-(1'H,3H-spiro[2-benzofuran-1,4'-piperidin]-1'-yl)propyl]-D-prolinamide dihydrochloride |
| BAN ORL 24 |
