CAS 97612-24-3|FLB 131
| Common Name | FLB 131 | ||
|---|---|---|---|
| CAS Number | 97612-24-3 | Molecular Weight | 377.306 |
| Density | / | Boiling Point | / |
| Molecular Formula | C17H26Cl2N2O3 | Melting Point | 144 - 146 °C |
| MSDS | USA | Flash Point | / |
Names
| Name | S-(-)-Eticlopride hydrochloride |
|---|---|
| Synonym | More Synonyms |
FLB 131 BiologicalActivity
| Description | Eticlopride hydrochloride, a selective dopamine D2‐like receptor antagonist, exhibits high affinity for dopamine D2, α1‐adrenergic, α2‐adrenergic, 5HT1, 5HT2 receptors with Kis of 0.09, 112, 699, 6220, and 830 nM, respectively. Antipsychotic agent[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease |
| Target | D2 Receptor:0.09 nM (Ki) |
| References | [1]. Jennifer L Martelle, et al. A review of the discovery, pharmacological characterization, and behavioral effects of the dopamine D2-like receptor antagonist eticlopride. CNS Neurosci Ther. Fall 2008;14(3):248-62. |
Chemical & Physical Properties
| Melting Point | 144 - 146 °C |
|---|---|
| Molecular Formula | C17H26Cl2N2O3 |
| Molecular Weight | 377.306 |
| Exact Mass | 376.132050 |
| InChIKey | HFJFXXDHVWLIKX-YDALLXLXSA-N |
| SMILES | CCc1cc(Cl)c(OC)c(C(=O)NCC2CCCN2CC)c1O.Cl |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| RTECS | CV2450000 |
Articles5
More Articles| Dopamine D2 receptor activity modulates Akt signaling and alters GABAergic neuron development and motor behavior in zebrafish larvae. J. Neurosci. 31 , 5512-25, (2011) An imbalance in dopamine-mediated neurotransmission is a hallmark physiological feature of neuropsychiatric disorders, such as schizophrenia. Recent evidence demonstrates that dopamine D(2) receptors,... | |
| Dopamine D2 receptors are involved in the regulation of Fyn and metabotropic glutamate receptor 5 phosphorylation in the rat striatum in vivo. J. Neurosci. Res. 94 , 329-38, (2016) Fyn, a major Src family kinase (SFK) member that is densely expressed in striatal neurons, is actively involved in the regulation of cellular and synaptic activities in local neurons. This SFK member ... | |
| Some in vitro receptor binding properties of [3H]eticlopride, a novel substituted benzamide, selective for dopamine-D2 receptors in the rat brain. Eur. J. Pharmacol. 111 , 191-199, (1985) The substituted benzamide compound eticlopride, (S)-(-)-5-chloro-3-ethyl-N-[(1-ethyl-2-pyrrolidinyl) methyl]-6-methoxysalicylamide hydrochloride (FLB 131), has been shown to selectively block dopamine... |
Synonyms
| (2S)-2-{[(3-Chloro-5-ethyl-6-hydroxy-2-methoxybenzoyl)amino]methyl}-1-ethylpyrrolidinium chloride |
| 3-Chloro-5-ethyl-N-{[(2S)-1-ethylpyrrolidin-2-yl]methyl}-6-hydroxy-2-methoxybenzamide hydrochloride (1:1) |
| Pyrrolidinium, 2-[[(3-chloro-5-ethyl-6-hydroxy-2-methoxybenzoyl)amino]methyl]-1-ethyl-, chloride, (2S)- (1:1) |
| MFCD00055132 |
