Introduction：Basic information about CAS 1700663-41-7|EPZ020411 HCl, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | EPZ020411 HCl |
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| CAS Number | 1700663-41-7 | Molecular Weight | 442.594 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 619.2±55.0 °C at 760 mmHg |
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| Molecular Formula | C25H38N4O3 | Melting Point | / |
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| MSDS | / | Flash Point | 328.3±31.5 °C |
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Names
| Name | N,N'-Dimethyl-N-({3-[4-({trans-3-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]cyclobutyl}oxy)phenyl]-1H-pyrazol-4-yl}methyl)-1,2-ethanediamine |
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| Synonym | More Synonyms |
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EPZ020411 HCl BiologicalActivity
| Description | EPZ020411 is a potent and selective inhibitor of PRMT6 with IC50 of 10 nM, has ＞10 fold selectivity for PRMT6 over PRMT1 and PRMT8.IC50 value: 10 nMTarget: PRMT6in vitro: EPZ020411 inhibits methylation of PRMT6 substrates in cells. EPZ020411 does-dependently inhibits H3R2 methylation in PRMT6-overexpressing cells.in vivo: EPZ020411 shows good bioavailability following subcutaneous (SC) dosing in rats making it a suitable tool for in vivo studies. |
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| Related Catalog | Signaling Pathways >>Epigenetics >>Histone MethyltransferaseResearch Areas >>Cancer |
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| References | [1]. Mitchell LH, et al. Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 ToolCompound. ACS Med Chem Lett. 2015 Apr 6;6(6):655-659. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 619.2±55.0 °C at 760 mmHg |
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| Molecular Formula | C25H38N4O3 |
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| Molecular Weight | 442.594 |
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| Flash Point | 328.3±31.5 °C |
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| Exact Mass | 442.294403 |
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| LogP | 1.92 |
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| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
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| Index of Refraction | 1.579 |
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| InChIKey | QMDKVNSQXPVCRD-UHFFFAOYSA-N |
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| SMILES | CNCCN(C)Cc1cn[nH]c1-c1ccc(OC2CC(OCCC3CCOCC3)C2)cc1 |
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| Storage condition | -20℃ |
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Synonyms
| N,N'-Dimethyl-N-({3-[4-({trans-3-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]cyclobutyl}oxy)phenyl]-1H-pyrazol-4-yl}methyl)-1,2-ethanediamine |
| 1,2-Ethanediamine, N,N-dimethyl-N-[[3-[4-[[trans-3-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]cyclobutyl]oxy]phenyl]-1H-pyrazol-4-yl]methyl]- |
| EPZ020411 HCl |
| EPZ020411 |
