Introduction：Basic information about CAS 1796565-52-0|Orexin 2 Receptor Agonist, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Orexin 2 Receptor Agonist |
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| CAS Number | 1796565-52-0 | Molecular Weight | 586.701 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C32H34N4O5S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 4'-Methoxy-N,N-dimethyl-3'-{[3-({2-[(3-methylbenzoyl)amino]ethyl}amino)phenyl]sulfamoyl}-3-biphenylcarboxamide |
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| Synonym | More Synonyms |
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Orexin 2 Receptor Agonist BiologicalActivity
| Description | Orexin 2 Receptor Agonist is a potent (EC50 on OX2R is 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio is 70) agonist.IC50 value: 23 nM (EC50)Target: Orexin 2 ReceptorOrexin 2 Receptor Agonist shows not only potentactivity but also high selectivity for OX2R over OX1R. In CHO cells overexpressing hOX1R and HEK-293 cells overexpressing hOX2R, compound 26 displaced [125I]orexin-A in a concentration dependent manner: 26 bound to hOX2R and hOX1R with Ki of 0.14 and 0.77 μM, respectively.[1] |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Orexin Receptor (OX Receptor)Research Areas >>Neurological Disease |
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| References | [1]. Nagahara T, et al. Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists. J Med Chem. 2015 Oct 22;58(20):7931-7. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Molecular Formula | C32H34N4O5S |
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| Molecular Weight | 586.701 |
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| Exact Mass | 586.224976 |
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| LogP | 3.40 |
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| Index of Refraction | 1.629 |
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| InChIKey | RHLMXWCISNJNDH-UHFFFAOYSA-N |
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| SMILES | COc1ccc(-c2cccc(C(=O)N(C)C)c2)cc1S(=O)(=O)Nc1cccc(NCCNC(=O)c2cccc(C)c2)c1 |
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| Storage condition | 2-8℃ |
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Synonyms
| Benzamide, N-[2-[[3-[[[3'-[(dimethylamino)carbonyl]-4-methoxy[1,1'-biphenyl]-3-yl]sulfonyl]amino]phenyl]amino]ethyl]-3-methyl- |
| 4'-Methoxy-N,N-dimethyl-3'-{[3-({2-[(3-methylbenzoyl)amino]ethyl}amino)phenyl]sulfamoyl}-3-biphenylcarboxamide |
| Orexin 2 Receptor Agonist |
| MDK-5220 |
