Introduction：Basic information about CAS 1809249-37-3|Remdesivir, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Remdesivir |
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| CAS Number | 1809249-37-3 | Molecular Weight | 602.576 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C27H35N6O8P | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | remdesivir |
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| Synonym | More Synonyms |
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Remdesivir BiologicalActivity
| Description | Remdesivir is a nucleoside analogue, with effective antiviral activity, with EC50s of 74 nM for ARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA SynthesisSignaling Pathways >>Anti-infection >>SARS-CoV |
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| Target | EC50: 30 nM (murine hepatitis virus, delayed brain tumor cell), 74 nM (SARS-CoV, HAE cell), 74 nM (MERS-CoV, HAE cell)[1] |
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| In Vitro | Remdesivir (GS-5734) is a potent antiviral agent. Remdesivir inhibits murine hepatitis virus (MHV) with an EC50 of 30 nM, and blocks SARS-CoV and MERS-CoV in HAE cells with EC50s of both 74 nM in HAE cells after treatment for 24 h[1]. |
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| References | [1]. Agostini ML, et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. MBio. 2018 Mar 6;9(2). pii: e00221-18. [2]. Wang M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Molecular Formula | C27H35N6O8P |
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| Molecular Weight | 602.576 |
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| Exact Mass | 602.225403 |
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| LogP | 2.10 |
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| Index of Refraction | 1.652 |
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| Storage condition | 2-8℃ |
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Synonyms
| UNII:3QKI37EEHE |
| GS-5734 |
| remdesivir |
