Introduction：Basic information about CAS 188196-22-7|frakefamide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | frakefamide |
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| CAS Number | 188196-22-7 | Molecular Weight | 563.620 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 897.9±65.0 °C at 760 mmHg |
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| Molecular Formula | C30H34FN5O5 | Melting Point | / |
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| MSDS | / | Flash Point | 496.8±34.3 °C |
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Names
| Name | frakefamide |
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| Synonym | More Synonyms |
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frakefamide BiologicalActivity
| Description | Frakefamide is a potent analgesic that acts as a peripheral active μ-selective receptor agonist. Frakefamide is unable to penetrate the blood-brain-barrier and enter the central nervous system[1][2]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Opioid ReceptorSignaling Pathways >>Neuronal Signaling >>Opioid ReceptorResearch Areas >>Neurological Disease |
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| In Vivo | Frakefamide (LEF576) yields a dose dependent increase in morphine appropriate responding to 50% at the highest dose tested (10 μmol/kg) after infusion durations of 2 min, whereas after 15 min infusions a maximum of 25% morphine appropriate responding was occasioned at 17.5 μmol/kg[1][2]. |
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| References | [1]. Modalen AO, et al. A novel molecule (frakefamide) with peripheral opioid properties: the effects on resting ventilation compared with morphine and placebo. Anesth Analg. 2005 Mar;100(3):713-7. [2]. Swedberg MD, et al. Drug discrimination: A versatile tool for characterization of CNS safety pharmacology and potential for drug abuse. J Pharmacol Toxicol Methods. 2016 Sep-Oct;81:295-305. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 897.9±65.0 °C at 760 mmHg |
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| Molecular Formula | C30H34FN5O5 |
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| Molecular Weight | 563.620 |
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| Flash Point | 496.8±34.3 °C |
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| Exact Mass | 563.254395 |
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| LogP | 1.45 |
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| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
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| Index of Refraction | 1.610 |
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| InChIKey | GTPHQORJKFJIRB-JTQLPTLWSA-N |
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| SMILES | CC(NC(=O)C(N)Cc1ccc(O)cc1)C(=O)NC(Cc1ccc(F)cc1)C(=O)NC(Cc1ccccc1)C(N)=O |
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Synonyms
| L-Phenylalaninamide, 4-fluoro-L-phenylalanyl-N-[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)-1-oxopropyl]amino]-1-oxopropyl]- |
| 4-Fluoro-L-phenylalanyl-N-[(2R)-2-(L-tyrosylamino)propanoyl]-L-phenylalaninamide |
| frakefamide |
