CAS 187100-75-0|Myristoyl coenzyme A lithium salt

Introduction：Basic information about CAS 187100-75-0|Myristoyl coenzyme A lithium salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Myristoyl coenzyme A lithium salt BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles3

Common Name	Myristoyl coenzyme A lithium salt
CAS Number	187100-75-0	Molecular Weight	1001.62
Density	/	Boiling Point	/
Molecular Formula	C₃₅H₅₈Li₄N₇O₁₇P₃S	Melting Point	/
MSDS	USA	Flash Point	/

Names

Name	MYRISTOYL COENZYME A C14:0 LITHIUM SALT

Myristoyl coenzyme A lithium salt BiologicalActivity

Description	Myristoyl coenzyme A lithium is lithium-labeled myristoylated coenzyme A (CoA). Myristoylation is an essential process in viruses and is generally controlled by N-myristoyltransferase (NMT). And NMT is more active in colon epithelial tumors than in normal cells. Reduced Ccoenzyme A (CoA) is known to be a key regulator of NMT activity, whereas oxidized CoA does not allow NMT to promote myristoylation. Myristoyl coenzyme A blocks the demyristoylation process and has potential anticancer and antiviral mechanisms.
Related Catalog	Research Areas >>CancerResearch Areas >>Infection
Target	Human Endogenous Metabolite
References	[1]. Raju RV, et al. Coenzyme A dependent myristoylation and demyristoylation in the regulation of bovine spleen N-myristoyltransferase. Mol Cell Biochem. 1996 May 24;158(2):107-13.

Chemical & Physical Properties

Molecular Formula	C₃₅H₅₈Li₄N₇O₁₇P₃S
Molecular Weight	1001.62
InChIKey	DMIGQCYHWKIMOK-RUVUOEETSA-J
SMILES	CCCCCCCCCCCCCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)([O-])OP(=O)([O-])OCC1OC(n2cnc3c(N)ncnc32)C(O)C1OP(=O)([O-])[O-].[Li+].[Li+].[Li+].[Li+]
Storage condition	−20°C

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

Articles3

Functional significance of myristoyl moiety in N-myristoyl proteins.

Meth. Enzymol. 250 , 405, (1995)

Fatty acid elongation in yeast--biochemical characteristics of the enzyme system and isolation of elongation-defective mutants.

Eur. J. Biochem. 252 , 477-485, (1998)

Elongation of long-chain fatty acids was investigated in yeast mutants lacking endogenous de novo fatty acid synthesis. In this background, in vitro fatty acid elongation was dependent strictly on the...

Modification of GTP-activated calcium translocation by fatty acyl-CoA esters. Evidence for a GTP-induced prefusion event.

J. Biol. Chem. 269 , 31607, (1994)

A sensitive and specific GTP-activated Ca2+ translocation process induces rapid Ca2+ movements within cells and appears to reflect G protein-induced membrane fusion or junctional communication between...

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