CAS 71997-40-5|ADENOSINE 5'-TRIPHOSPHATE,PERIODATE OXIDIZED SODIUM SALT
| Common Name | ADENOSINE 5'-TRIPHOSPHATE,PERIODATE OXIDIZED SODIUM SALT | ||
|---|---|---|---|
| CAS Number | 71997-40-5 | Molecular Weight | 571.11 |
| Density | / | Boiling Point | / |
| Molecular Formula | C10H11N5Na3O13P3 | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | Oxidized ATP (oATP) trisodium salt is a broad-spectrum P2 receptor inhibitor. Oxidized ATP trisodium salt irreversibly antagonizes P2X7R activation. Oxidized ATP trisodium salt inhibits c-reactive protein (CRP)-induced NLRP3 inflammasome activation. Oxidized ATP trisodium salt can be used for research of atherosclerosis[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>NOD-like Receptor (NLR)Research Areas >>Inflammation/ImmunologySignaling Pathways >>Membrane Transporter/Ion Channel >>P2X Receptor |
| Target | NLRP3 inflammasome P2X7 Receptor |
| In Vivo | Oxidized ATP (300 μg/mouse, i.p., twice a week) trisodium salt ameliorates the induced mouse experimental autoimmune uveitis (EAU) in B6 mice[2]. Animal Model: Induced mouse experimental autoimmune uveitis (EAU)[2] Dosage: 300 μg/mouse Administration: i.p. Result: Showed almost undetected EAU, as shown by fundoscopic and pathologic examination. Decreased serum IL-17 level. Mitigated the autoreactive T cell response. |
| References | [1]. Bian F, et al. CRP-Induced NLRP3 Inflammasome Activation Increases LDL Transcytosis Across Endothelial Cells. Front Pharmacol. 2019 Jan 30;10:40. [2]. Zhao R, et al. Blockade of Extracellular ATP Effect by Oxidized ATP Effectively Mitigated Induced Mouse Experimental Autoimmune Uveitis (EAU). PLoS One. 2016 May 19;11(5):e0155953. |
Chemical & Physical Properties
| Molecular Formula | C10H11N5Na3O13P3 |
|---|---|
| Molecular Weight | 571.11 |
| InChIKey | HNIAWAXYNDLLTR-ZJLYAJKPSA-M |
| SMILES | Nc1ncnc2c1ncn2C(C=O)OC(C=O)COP(=O)(O)OP(=O)(O)OP(=O)([O-])O.[Na+] |
| Storage condition | −20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles29
More Articles| Involvement of a P2X7 Receptor in the Acrosome Reaction Induced by ATP in Rat Spermatozoa. J. Cell Physiol. 230 , 3068-75, (2015) The acrosome reaction (AR) is the exocytosis of the acrosomal vesicle in response to different physiological and non-physiological stimuli. Particularly in mammals, the AR is needed for sperm to fuse ... | |
| P2X1 Receptor Antagonists Inhibit HIV-1 Fusion by Blocking Virus-Coreceptor Interactions. J. Virol. 89 , 9368-82, (2015) HIV-1 Env glycoprotein-mediated fusion is initiated upon sequential binding of Env to CD4 and the coreceptor CXCR4 or CCR5. Whereas these interactions are thought to be necessary and sufficient to pro... | |
| Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases, resulting in cytokine imbalance. Proc. Natl. Acad. Sci. U. S. A. 112(9) , 2835-40, (2015) Cell stress is implicated in triggering bouts of systemic inflammation in patients with autoinflammatory disorders. Blood monocytes from patients affected by NLRP3-mediated cryopyrin-associated period... |
Synonyms
| MFCD00056956 |
