CAS 799840-96-3|Maytansinoid dM4

Introduction：Basic information about CAS 799840-96-3|Maytansinoid dM4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Maytansinoid dM4 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Maytansinoid dM4
CAS Number	799840-96-3	Molecular Weight	794.394
Density	1.3±0.1 g/cm3	Boiling Point	940.2±65.0 °C at 760 mmHg
Molecular Formula	C₃₉H₅₆ClN₃O₁₀S	Melting Point	/
MSDS	/	Flash Point	522.4±34.3 °C

Names

Name	Maytansinoid dM4
Synonym	More Synonyms

Maytansinoid dM4 BiologicalActivity

Description	Maytansinoid DM4 is a thiol-containing maytansine derivative with highly potent cytotoxicity. Maytansinoid DM4 can be used as a cytotoxic moiety of ADC[1][2].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC Cytotoxin
Target	Maytansinoids
In Vitro	Maytansine is a natural benzoansamacrolide product isolated from the bark of the African shrub Maytenus ovatus. Maytansine binds to the same site on tubulin as the vinca alkaloids, with similar in vitro inhibition constants, but is a more-potent cytotoxin[1].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [2]. Zhao RY, et al. Synthesis and evaluation of hydrophilic linkers for antibody-maytansinoid conjugates. J Med Chem. 2011 May 26;54(10):3606-23.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	940.2±65.0 °C at 760 mmHg
Molecular Formula	C₃₉H₅₆ClN₃O₁₀S
Molecular Weight	794.394
Flash Point	522.4±34.3 °C
Exact Mass	793.337463
LogP	6.26
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.587
InChIKey	SVVGCFZPFZGWRG-QEGJILGISA-N
SMILES	COc1cc2cc(c1Cl)N(C)C(=O)CC(OC(=O)C(C)N(C)C(=O)CCC(C)(C)S)C1(C)OC1C(C)(C)C1CC(O)(NC(=O)O1)C(OC)C=CC=C(C)C2

Synonyms

MFCD28144633

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