CAS 98072-47-0|Streptolysin O
| Common Name | Streptolysin O | ||
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| CAS Number | 98072-47-0 | Molecular Weight | / |
| Density | / | Boiling Point | / |
| Molecular Formula | / | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | STREPTOLYSIN O |
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| Synonym | More Synonyms |
Streptolysin O BiologicalActivity
| Description | Streptolysin O, a group A streptococcal toxin, is a well-characterized oxygen-labile prototype of a cholesterol-binding bacterial exotoxin. Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state [1][2][3][4]. |
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| Related Catalog | Research Areas >>Infection |
| In Vitro | When Streptolysin O is secreted by streptococci, it is in an active state, but it rapidly oxidizes to a reversibly inactive state with the formation of disulfide bonds[2]. Streptolysin O, belongs to the group of thiol-activated toxins, is a secreted virulence factor of GAS that induces apoptosis in neutrophils and macrophages at later time points (~4 h). Streptolysin O induces eukaryotic cell lysis in a cholesterol-dependent manner, is highly upregulated in the GAS M1T1 clone during bloodstream dissemination. Streptolysin O is known to promote Group A Streptococcus (GAS) resistance to phagocytic clearance by neutrophils, a critical first element of host defense against invasive bacterial infection[3]. |
| References | [1]. Sierig G, et al. Cytotoxic effects of streptolysin o and streptolysin s enhance the virulence of poorlyencapsulated group a streptococci. Infect Immun. 2003 Jan;71(1):446-55. [2]. Van Epps DE, et al. Streptolysin O II. Relationship of Sulfyhdryl Groups to Activity. Infect Immun. 1971 May;3(5):648-52. [3]. Uchiyama S, et al. Streptolysin O Rapidly Impairs Neutrophil Oxidative Burst and Antibacterial Responses to Group A Streptococcus. Front Immunol. 2015 Nov 16;6:581. [4]. Yamamoto I, et al. Mutational and comparative analysis of streptolysin O, an oxygen-labile streptococcal hemolysin. Biosci Biotechnol Biochem. 2001 Dec;65(12):2682-9. |
Chemical & Physical Properties
| Appearance of Characters | lyophilized powder |
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| InChIKey | OUNBUOICPMHVPB-UHFFFAOYSA-N |
| SMILES | [Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y].[Y] |
| Storage condition | 2-8°C |
| Water Solubility | H2O: soluble1mg/mL |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | UN 2811PIH 6.1 / PGI |
| WGK Germany | 3 |
Articles3
More Articles| Suicide cancer gene therapy using pore-forming toxin, streptolysin O. Mol. Cancer Ther. 5 , 1610-1619, (2006) We cloned the streptolysin O gene from the Streptococcus pyogenes genome and tested the possibility of using it as an anticancer reagent. Transient transfection of the streptolysin O gene efficiently ... | |
| Inhibition of streptolysin O by allicin - an active component of garlic. J. Med. Microbiol. 59 , 1044-1049, (2010) Streptolysin O (SLO) is a potent cytolytic toxin produced by almost all strains of group A streptococci and is considered an important virulence factor for this organism. In this study we investigated... | |
| Neurotransmitter interactions related to central dopamine neurons. Essays Neurochem. Neuropharmacol. 3 , 129-207, (1978) |
Synonyms
| EINECS 308-500-3 |
