Introduction：Basic information about CAS 942123-43-5|Inarigivir soproxil, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Inarigivir soproxil |
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| CAS Number | 942123-43-5 | Molecular Weight | 703.615 |
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| Density | 1.8±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C25H34N7O13PS | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | inarigivir soproxil |
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| Synonym | More Synonyms |
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Inarigivir soproxil BiologicalActivity
| Description | Inarigivir soproxil is an agonist of innate immunity and shows potent antiviral activity against resistant hepatitis C virus (HCV) variants, with EC50s of 2.2 and 1.0 μM for HCV 1a/1b in cells of genotype 1 HCV replicon systems. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>HCVResearch Areas >>Infection |
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| Target | EC50: 2.2/1.0 μM (HCV 1a/1b)[1]. |
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| In Vitro | Inarigivir soproxil (SB 9200) is an oral modulator of innate immunity that is believed to act via the activation of the RIG-I and NOD2 pathways. SB 9200 has broad-spectrum antiviral activity against RNA viruses including hepatitis C virus (HCV), norovirus, respiratory syncytial virus and influenza and has demonstrated activity against hepatitis B virus (HBV). Inarigivir soproxil is shown to inhibit HCV replication and the range of inhibition is comparable between genotypes 1a and 1b. Inarigivir soproxil demonstrates pan-genotypic antiviral activity against HCV. Inarigivir soproxil is active against DAA-resistant HCV variants[1]. |
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| References | [1]. Jones M, ET AL. SB 9200, a novel agonist of innate immunity, shows potent antiviral activity against resistant HCV variants. J Med Virol. 2017 Sep;89(9):1620-1628. |
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Chemical & Physical Properties
| Density | 1.8±0.1 g/cm3 |
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| Molecular Formula | C25H34N7O13PS |
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| Molecular Weight | 703.615 |
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| Exact Mass | 703.167297 |
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| LogP | -0.66 |
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| Index of Refraction | 1.732 |
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| InChIKey | CJCYTUJOSMYXLE-JDLSZIHUSA-N |
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| SMILES | COC1C(OP(=O)(OCC2OC(n3cnc4c(N)ncnc43)CC2O)SCOC(=O)OC(C)C)C(CO)OC1n1ccc(=O)[nH]c1=O |
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| Storage condition | 2-8℃ |
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Synonyms
| inarigivir soproxil |
| [({[(2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-3-hydroxytetrahydro-2-furanyl]methoxy}{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl)-2-(hydroxymethyl)-4-methoxytetrahydro-3-furanyl]oxy}phosphoryl)sulfanyl]methyl isopropyl carbonate |
| 365052M0DK |
