CAS 946525-65-1|Velagliflozin

Introduction：Basic information about CAS 946525-65-1|Velagliflozin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Velagliflozin BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Velagliflozin
CAS Number	946525-65-1	Molecular Weight	395.448
Density	1.4±0.1 g/cm3	Boiling Point	648.6±55.0 °C at 760 mmHg
Molecular Formula	C₂₃H₂₅NO₅	Melting Point	/
MSDS	/	Flash Point	346.1±31.5 °C

Names

Name	velagliflozin
Synonym	More Synonyms

Velagliflozin BiologicalActivity

Description	Velagliflozin is an orally available sodium-glucose cotransporter 2 (SGLT2) inhibitor, with anti-diabetic activity.
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>SGLTResearch Areas >>Metabolic Disease
Target	SGLT2[1]
In Vitro	Velagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, with anti-diabetic activity[1].
In Vivo	Velagliflozin (1 mg/kg, p.o.) increases cholesterol, albumin, beta-hydroxybutyrate (BHB), nonesterified fatty acids (NEFA), and urinary glucose excretion, and decreases respiratory exchange ratio in cats[1].
References	[1]. Hoenig M, et al. Effects of the sodium-glucose cotransporter 2 (SGLT2) inhibitor velagliflozin, a new drug with therapeutic potential to treat diabetes in cats. J Vet Pharmacol Ther. 2018 Apr;41(2):266-273.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	648.6±55.0 °C at 760 mmHg
Molecular Formula	C₂₃H₂₅NO₅
Molecular Weight	395.448
Flash Point	346.1±31.5 °C
Exact Mass	395.173279
LogP	3.87
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.670
InChIKey	SENUNDCNOYAWGN-ZQGJOIPISA-N
SMILES	N#Cc1ccc(C2OC(CO)C(O)C(O)C2O)cc1Cc1ccc(C2CC2)cc1
Storage condition	-20°C

Synonyms

velagliflozin

(1S)-1,5-Anhydro-1-[4-cyano-3-(4-cyclopropylbenzyl)phenyl]-D-glucitol

UNII:FV2YU8SL0P

D-Glucitol, 1,5-anhydro-1-C-[4-cyano-3-[(4-cyclopropylphenyl)methyl]phenyl]-, (1S)-

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