Introduction：Basic information about (-)-Corey lactone 4-phenylbenzoate alcohol CAS 31752-99-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
(-)-Corey lactone 4-phenylbenzoate alcohol Basic informationDescription
| Product Name: | (-)-Corey lactone 4-phenylbenzoate alcohol |
| Synonyms: | (3AALPHA,4ALPHA,5BETA,6AALPHA)-(-)-HEXAHYDRO-4-(HYDROXYMETHYL)-2-OXO-2H-CYCLOPENTA[B]FURAN-5-YL 1,1'-BIPHENYL-4-CARBOXYLATE;4-Phenylbenzoyl corey lactone;(-)-COREY LACTONE 4-PHENYLBENZOATE ALCOHOL 99%;(-)-COREY LACTONE, 4-PHENYLBENZOATE ALCOHOL;(3aR,4S,5R,6aS)-Hexahydro-4-hydroxymethyl-5-(4-phenylbenzoyloxy)cyclopenta[b]furan-2-one, 99%;[1,1'-Biphenyl]-4-carboxylicacid,(3aR,4S,5R,6aS)-hexahydro-4-(hydroxymethyl)-2-oxo-2H-cyclopenta[b]furan-5-ylester;BPCOD;Corey Lactone p-Phenyl |
| CAS: | 31752-99-5 |
| MF: | C21H20O5 |
| MW: | 352.38 |
| EINECS: | 608-667-5 |
| Product Categories: | Prostaglandins;Latanoprost;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 31752-99-5.mol |
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(-)-Corey lactone 4-phenylbenzoate alcohol Chemical Properties
| Melting point | 131-132 °C(lit.) |
| alpha | -89 º (c=1, CHCl3) |
| Boiling point | 446°C (rough estimate) |
| density | 1.1818 (rough estimate) |
| refractive index | 1.5400 (estimate) |
| storage temp. | 2-8°C |
| solubility | Chloroform, Ethyl Acetate |
| pka | 14.79±0.10(Predicted) |
| form | Solid |
| color | Off-White to Pale Yellow |
| Optical Rotation | [α]20/D 87°, c = 1 in chloroform |
| Water Solubility | insoluble |
| BRN | 1294692 |
| InChI | 1S/C21H20O5/c22-12-17-16-10-20(23)25-18(16)11-19(17)26-21(24)15-8-6-14(7-9-15)13-4-2-1-3-5-13/h1-9,16-19,22H,10-12H2/t16-,17-,18+,19-/m1/s1 |
| InChIKey | SZJVIFMPKWMGSX-UHFFFAOYSA-N |
| SMILES | OC[C@H]1[C@@H](C[C@@H]2OC(=O)C[C@H]12)OC(=O)c3ccc(cc3)-c4ccccc4 |
| CAS DataBase Reference | 31752-99-5(CAS DataBase Reference) |
Safety Information
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| HS Code | 29322090 |
| Storage Class | 11 - Combustible Solids |
(-)-Corey lactone 4-phenylbenzoate alcohol Usage And Synthesis
| Description | (-)-Corey lactone 4-phenylbenzoate alcohol is one of the isomers of biphenyl-4-formylcorilactone, which can be used for the synthesis of prostaglandins. Prostaglandins are a class of important endogenous physiologically active substances, important mediators of various physiological processes, and have high pharmacological activity. Clinically, prostaglandins are all artificially synthesized. |
| Chemical Properties | Off-White to Pale Yellow Solid |
| Uses | (-) Corey lactone phenylbenzoate is a key intermediate in the synthesis of prostaglandins. Versatile building block for prostaglandins. Building block for a potent and selective antiglaucoma agent analog of PGF2α. |
(-)-Corey lactone 4-phenylbenzoate alcohol Preparation Products And Raw materials
| Preparation Products | (+)-(3AR,4R,5R,6AS)-HEXAHYDRO-5-HYDROXY-4-[(1E,3R)-3-HYDROXY-4-(3-TRIFLUOROMETHYL)PHENOXY-1-BUTENYL]-2H-CYCLOPENTA[B]FURAN-2-ONE-->(+)-Cloprostenol-->Latanoprost Lactone Diol-->[1,1'-Biphenyl]-4-carboxylic acid [3aR-[3aa,4a(E),5b,6aa]]-4-[4-(3-chlorophenoxy)-3-oxo-1-butenyl]hexahydro-2-oxo-2H-cyclopenta[b]furan-5-yl ester-->[1,1'-Biphenyl]-4-carboxylic acid (3aR,4R,5R,6aS)-hexahydro-2-oxo-4-[(1E)-3-oxo-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-2H-cyclopenta[b]furan-5-yl ester |
