Introduction：Basic information about (-)-Corey lactone diol CAS 32233-40-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
(-)-Corey lactone diol Basic information
| Product Name: | (-)-Corey lactone diol |
| Synonyms: | (-) COREY LACTONE DIOL;(-)-COREY LACTONE DIOL,98%;(3AR,4S,5R,6AS)-(-)-HEXAHYDRO-5-HYDROXY-4--2H-CYCLOPENTA(B)FURAN-2-ONE,;(1R)-2β-(Hydroxymethyl)-3α,5α-dihydroxycyclopentane-1α-acetic acid 1,5-lactone;(1S,5R,6S,7R)-7-Hydroxy-6-hydroxymethyl-2-oxabicyclo[3.3.0]octan-3-one;(3aβ,4S,6aβ)-4β-(Hydroxymethyl)-5α-hydroxyhexahydro-2H-cyclopenta[b]furan-2-one;(-)-6beta-Hydroxymethyl-7alpha-hydroxy-cis-2-oxabicyclo[3.3.0]octan-3-one,98%;(+)-6β-Hydroxymethyl-7α-hydroxy-cis-2-oxabicyclo[3.3.0]octan-3-one |
| CAS: | 32233-40-2 |
| MF: | C8H12O4 |
| MW: | 172.18 |
| EINECS: | 608-721-8 |
| Product Categories: | Latanoprost;Prostaglandins;API |
| Mol File: | 32233-40-2.mol |
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(-)-Corey lactone diol Chemical Properties
| Melting point | 117-119 °C(lit.) |
| Boiling point | 262.49°C (rough estimate) |
| density | 1.2104 (rough estimate) |
| refractive index | 1.4455 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 14.36±0.40(Predicted) |
| form | Crystalline Powder or Crystals |
| color | White to beige-brown |
| Optical Rotation | [α]20/D 44°, c = 1.4 in methanol |
| InChI | InChI=1S/C8H12O4/c9-3-5-4-1-8(11)12-7(4)2-6(5)10/h4-7,9-10H,1-3H2/t4-,5-,6-,7+/m1/s1 |
| InChIKey | VYTZWRCSPHQSFX-GBNDHIKLSA-N |
| SMILES | O1C(=O)C[C@]2([H])[C@@H](CO)[C@H](O)C[C@]12[H] |
| CAS DataBase Reference | 32233-40-2(CAS DataBase Reference) |
Safety Information
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| HS Code | 29322090 |
| Storage Class | 11 - Combustible Solids |
(-)-Corey lactone diol Usage And Synthesis
| Chemical Properties | white to beige-brown cryst. powder or crystals |
| Uses | (-)-Corey Lactone Diol is an intermediate of Iloprost (I267300) and shows inhibitory activity towards β-lactamase. Iloprost (I267300) is a synthetic analogue of Prostacyclin (PGI2) used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud''s phenomenon and ischemia. |
| Definition | ChEBI: (-)-corey lactone is a gamma-lactone. |
(-)-Corey lactone diol Preparation Products And Raw materials
| Raw materials | 2H-Cyclopenta[b]furan-2-one, 5-(acetyloxy)hexahydro-4-(hydroxymethyl)-, (3aR,4S,5R,6aS)--->117624-93-8-->(-)-Corey Lactone Benzoate-->(3aR,4S,5R,6aS)-4-[(Acetyloxy)methyl]hexahydro-5-hydroxy-2H-cyclopenta[b]furan-2-one-->((3aR,4S,6aS)-5-acetoxy-2-oxohexahydro-2H-cyclopenta[b]furan-4-yl)Methyl acetate |
| Preparation Products | 2H-Cyclopenta[b]furan-2-one, hexahydro-4-[(1E)-3-oxo-1-octen-1-yl]-5-[(triethylsilyl)oxy]-, (3aR,4R,5R,6aS)--->(+)-Cloprostenol-->2H-Cyclopenta[b]furan-4-carboxaldehyde, hexahydro-5-hydroxy-2-oxo-, (3aR,4R,5R,6aS)--->(3aR,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E)-3-oxo-1-octen-1-yl]-2H-cyclopenta[b]furan-2-one-->(-)-Corey lactone 4-phenylbenzoate alcohol |
