(±)-Cloprostenol sodium salt CAS 55028-72-3

Introduction：Basic information about (±)-Cloprostenol sodium salt CAS 55028-72-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

(±)-Cloprostenol sodium salt Basic information

• Product Name: (±)-Cloprostenol sodium salt
• Synonyms: 15-EPI CLOPROSTENOL;15(S)-CLOPROSTENOL;16-(3-CHLOROPHENOXY)-9,11,15R-TRIHYDROXY-17,18,19,20-TETRANORPROSTA-5Z,13E-DIEN-1-OIC ACID SODIUM SALT;(+)-16-M-CHLOROPHENOXY TETRANOR PROSTAGLANDIN F2ALPHA SODIUM SALT;7-(2-[4-(3-Chlorophenoxy)-3-hydroxy-1-butenyl]-3,5-dihydroxycyclopentyl)-5-heptenoic acid;(5Z)-rel-Cloprostenol SodiuM;DL-Cloprostenol sodiuM;(+/-)-16-(3-Chlorophenoxy)-9,11,15R-trihydroxy-17,18,19,20-tetranorprosta-5Z,13E-dien-1-oic acid hydrate sodium salt
• CAS: 55028-72-3
• MF: C22H30ClNaO6
• MW: 448.92
• EINECS: 259-439-3
• Product Categories: Other APIs;Pharmaceuticals;Prostaglandins;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceutical Raw Materials
• Mol File: 55028-72-3.mol

(±)-Cloprostenol sodium salt Chemical Properties

• Melting point: 68-70 °C
• storage temp.: Inert atmosphere,Store in freezer, under -20°C
• solubility: H₂O: >10 mg/mL
• form: solid
• color: light brown
• Water Solubility: H2O: >10mg/mL
• InChIKey: IFEJLMHZNQJGQU-KXXGZHCCSA-M
• SMILES: C([C@@H]1[C@@H](C[C@H](O)[C@H]1/C=C/[C@H](O)COC1C=CC=C(Cl)C=1)O)/C=C\CCCC(=O)O.[NaH] |&1:1,2,4,6,9,r|
• CAS DataBase Reference: 55028-72-3(CAS DataBase Reference)

Safety Information

• Hazard Codes: T
• Risk Statements: 60-22-36/37/38
• Safety Statements: 53-26-36/37/39-45
• WGK Germany: 3
• HS Code: 2937500000
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Oral Eye Irrit. 2 Repr. 2 Skin Irrit. 2 STOT SE 3

(±)-Cloprostenol sodium salt Usage And Synthesis

Uses

(±)-Cloprostenol sodium salt is a prostaglandin that dissolves the corpus luteum of cattle and is used as a veterinary drug.

Description

(±)-Cloprostenol sodium salt is the d-enantiomer of Cloprostenol (C587300), an aryl-oxymethyl analog of prostaglandin F2α.

Brand name

Estrumate(Bayer AnimalHealth).

General Description

Cloprostenol sodium (Estrumate)is available as the sodium salt from Bayer AgriculturalDivision or Bayvet Division of Miles Laboratory as an aqueoussolution containing 250 mg/mL.

Biological Activity

Water-soluble prostaglandin F 2 α (PGF 2 α ) analog; acts as a potent FP receptor agonist (EC 50 = 0.84 nM). Potently inhibits differentiation of adipocyte precursor cells. Luteolytic agent in vivo .

Side effects

A low incidence of clostridial and other infections at the injection site has been reported following prostaglandin administration. Treated animals should be closely observed post injection and appropriate antibiotic therapy initiated at the first sign(s) of infection.
Very rarely, anaphylactic reactions have occurred after administration of the product. Overdose: At 50 and 100 times the recommended dose of cloprostenol mild side effects may be detected. These include increased uneasiness, mild transient diarrhea, slight frothing, and milk letdown.

Veterinary Drugs and Treatments

Cloprostenol is approved for use in beef or dairy cattle to induceluteolysis. It is recommended by the manufacturer for unobservedor undetected estrus in cows cycling normally, pyometra or chronicendometritis, expulsion of mummified fetus, luteal cysts, inducedabortions after mismating, and to schedule estrus and ovulation forcontrolled breeding.
Cloprostenol has been used in dogs for pregnancy terminationand treatment of open pyometra. The use of cloprostenol for pyometrais controversial as some believe dinoprost (PGF2alpha) ismore effective and has fewer adverse effects than cloprostenol.

Solubility in water

Soluble in H₂O.