(S)-(-)-2-ACETOXYPROPIONYL CHLORIDE CAS 36394-75-9

Introduction：Basic information about (S)-(-)-2-ACETOXYPROPIONYL CHLORIDE CAS 36394-75-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

(S)-(-)-2-ACETOXYPROPIONYL CHLORIDE Basic information

• Product Name: (S)-(-)-2-ACETOXYPROPIONYL CHLORIDE
• Synonyms: (S)-(-)-O-ACETYLLACTOYL CHLORIDE;(S)-(-)-2-ACETOXYPROPIONYL CHLORIDE;(S)-2-ACETOXYPROPIONYL CHLORIDE;S-ACETOXYPROPIONYL CHLORIDE;O-ACETYL-L-LACTYL CHLORIDE;AP-CL;2-Acetoxy propionyl chloride;acetic acid (1-chloro-1-oxopropan-2-yl) ester
• CAS: 36394-75-9
• MF: C5H7ClO3
• MW: 150.56
• EINECS: 420-610-4
• Product Categories: synthons
• Mol File: 36394-75-9.mol

(S)-(-)-2-ACETOXYPROPIONYL CHLORIDE Chemical Properties

• alpha: -31o (C=4 IN CHLOROFORM)
• Boiling point: 50 °C5 mm Hg(lit.)
• density: 1.189 g/mL at 25 °C(lit.)
• refractive index: n20/D 1.423(lit.)
• Fp: >230 °F
• storage temp.: Inert atmosphere,2-8°C
• solubility: Chloroform (Sparingly)
• form: clear liquid
• Specific Gravity: 1.19
• color: Colorless to Light yellow
• Optical Rotation: [α]20/D 31°, c = 4 in chloroform
• BRN: 1722943
• Stability: Hygroscopic, Moisture sensitive
• InChI: InChI=1S/C5H7ClO3/c1-3(5(6)8)9-4(2)7/h3H,1-2H3/t3-/m0/s1
• InChIKey: ALHZEIINTQJLOT-VKHMYHEASA-N
• SMILES: C(Cl)(=O)[C@@H](OC(C)=O)C
• CAS DataBase Reference: 36394-75-9(CAS DataBase Reference)

Safety Information

• Hazard Codes: C
• Risk Statements: 34-43-22
• Safety Statements: 26-36/37/39-45-23
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• F: 10-21
• HazardClass: 8
• PackingGroup: III
• HS Code: 2918199890
• Storage Class: 8A - Combustible corrosive hazardous materials
• Hazard Classifications: Acute Tox. 4 Oral Skin Corr. 1B Skin Sens. 1

(S)-(-)-2-ACETOXYPROPIONYL CHLORIDE Usage And Synthesis

Uses

Frequently used chiral building block. Also used to resolve a bicyclic α-hydroxylactone and to prepare chiral phosphonates used in an enantiomeric excess assay of unprotected amino acids. Useful chiral derivatizing agent.

Purification Methods

It is moisture sensitive and is hydrolysed to the corresponding acid. Check the IR spectrum. If the OH band above 3000cm -1 is too large and broad then the mixture should be refluxed with pure acetyl chloride for 1hour, evaporated and distilled under reduced pressure. [Julia & Sans J Chromatographic Sci 17 651 1979, Dolittle & Heath J Org Chem 49 5041 1984, Beilstein 3 II 189.]