18BETA(H)-OLEAN-12-EN-3-ONE CAS 638-97-1

Introduction：Basic information about 18BETA(H)-OLEAN-12-EN-3-ONE CAS 638-97-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

18BETA(H)-OLEAN-12-EN-3-ONE Basic information

• Product Name: 18BETA(H)-OLEAN-12-EN-3-ONE
• Synonyms: 18BETA(H)-OLEAN-12-EN-3-ONE;Olean-12-en-3-one;β-Amyrone;beta-Amyrone;beta-AMyrenone;18(H)-Olean-12-en-3-one;(6aR,6bS,8aR,12aS,14aR,14bR)-4,4,6a,6b,8a,11,11,14b-octamethyl-2,4a,5,6,7,8,9,10,12,12a,14,14a-dodecahydro-1H-picen-3-one;β-Amyron
• CAS: 638-97-1
• MF: C30H48O
• MW: 424.7
• Mol File: 638-97-1.mol

18BETA(H)-OLEAN-12-EN-3-ONE Chemical Properties

• Melting point: 177-178 °C
• Boiling point: 488.3±45.0 °C(Predicted)
• density: 1.01±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• form: Solid
• color: White to off-white
• InChIKey: LIIFBMGUDSHTOU-CFYIDONUSA-N
• SMILES: C1(=O)[C@@]([C@]2([C@](C)(CC1)[C@]1([H])[C@@]([C@]3(C(=CC1)[C@]1([C@@](CC[C@](C1)(C)C)(C)CC3)[H])C)(C)CC2)[H])(C)C

18BETA(H)-OLEAN-12-EN-3-ONE Usage And Synthesis

Uses

β-Amyron is used as inhibitor of cyclooxygenase and lipoxygenase enzymes to study the structure-activity relationships of pentacyclic triterpenoids.

in vivo

β-Amyrone (local administration on ear, 0.1-0.6 mg/kg, a single dose) inhibits ear edema formation in phenol-induced edema mice^[1].

• Animal Model: Ear phenol-induced edema in Balb C mice^[1]
• Dosage: 0.1, 0.3, 0.6 mg/kg, a single dose
• Administration: Local administration (20 ??L solution) on ear
• Result: Inhibited ear edema formation in a dose-related manner (47% inhibition at the dose of 0.6mg/kg).

IC 50

COX-2