2,2,2-Trifluoroethylamine hydrochloride CAS 373-88-6
2,2,2-Trifluoroethylamine hydrochloride Basic information
| Product Name: | 2,2,2-Trifluoroethylamine hydrochloride |
| Synonyms: | 2,2,2-Trifluoroethyla;2,2,2-trifluoroethan-1-aMine chloride;2,2,2-trifluoroethanaminium chloride;2,2,2-TrifluoroethylaMine Hydrochloride, 97+%;TAF;TRIFLUOROETHYLAMINE HYDROCHLORIDE;2,2,2-TRIFLUOROETHYLAMINE HYDROCHLORIDE;2,2,2-TRIFLUORO-ETHYL-AMMONIUM CHLORIDE |
| CAS: | 373-88-6 |
| MF: | C2H5ClF3N |
| MW: | 135.52 |
| EINECS: | 206-771-1 |
| Product Categories: | |
| Mol File: | 373-88-6.mol |
2,2,2-Trifluoroethylamine hydrochloride Chemical Properties
| Melting point | 220-222 °C (subl.)(lit.) |
| density | 1,24g/cm |
| refractive index | 1,3-1,302 |
| storage temp. | Inert atmosphere,Room Temperature |
| form | powder to crystal |
| color | White to Light yellow to Light orange |
| Water Solubility | It is Soluble in 0.7 to water, but soluble in ethanol and chloroform, slightly soluble in benzene, hardly soluble in ether. |
| Sensitive | Hygroscopic |
| BRN | 3652103 |
| InChI | InChI=1S/C2H4F3N.ClH/c3-2(4,5)1-6;/h1,6H2;1H |
| InChIKey | ZTUJDPKOHPKRMO-UHFFFAOYSA-N |
| SMILES | C(F)(F)(F)CN.Cl |
| CAS DataBase Reference | 373-88-6(CAS DataBase Reference) |
| EPA Substance Registry System | Ethanamine, 2,2,2-trifluoro-, hydrochloride (373-88-6) |
Safety Information
| Hazard Codes | Xn,T,Xi |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 36/37-24/25-36-26 |
| WGK Germany | 3 |
| RTECS | KS0250000 |
| F | 3-10-21 |
| Hazard Note | Hygroscopic/Toxic |
| TSCA | TSCA listed |
| HazardClass | IRRITANT |
| PackingGroup | III |
| HS Code | 29211990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral |
| Toxicity | LD50 unr-mus: 476 mg/kg 11FYAN 3,81,63 |
| Chemical Properties | WHITE TO LIGHT YELLOW CRYSTALLINE POWDER |
| Uses | 2,2,2-Trifluoroethylamine Hydrochloride is a reagent in the synthesis of arachidonylethanolamide analogs. These show affinity for CB1 and CB2 cannabinoid receptors. |
| Safety Profile | Moderately toxic by unspecifiedroute. When heated to decomposition it emits very toxicfumes of F??, NOx, and HCl. |
| Synthesis | 753-90-2 373-88-6 General procedure for the synthesis of 2,2,2-trifluoroethylamine hydrochloride from 2,2,2-trifluoroethylamine: 100 g of ethanol and 33 g of 2,2,2-trifluoroethylamine were added to a triple-necked flask, and 35 g of saturated hydrochloric acid solution was added slowly and dropwise at temperatures lower than 25°C. The reaction system was then brought up to 50°C and maintained there for 1 hour. After the dropwise addition, the temperature of the reaction system was raised to 50 °C and maintained for 1 hour. Subsequently, the temperature of the reaction solution was controlled to be 45±5°C under a vacuum of 0.98 MPa and a decompression distillation was carried out for 5 hours to remove water and ethanol. Finally 43.5 g of 2,2,2-trifluoroethylamine hydrochloride was obtained in 96.30% yield. The resulting product was a white powdery crystalline solid with 0.13% water. |
| References | [1] Patent: CN105801428, 2016, A. Location in patent: Paragraph 0016; 0017 |
2,2,2-Trifluoroethylamine hydrochloride Preparation Products And Raw materials
| Raw materials | 2,2,2-TRIFLUOROETHYLAMINE-->Ethanol-->Water-->Hydrochloric acid |
| Preparation Products | 1-Bromo-4-(2,2,2-trifluoroethyl)benzene-->Benzenamine, 3-methoxy-N-(2,2,2-trifluoroethyl)--->Urea, N-methyl-N'-(2,2,2-trifluoroethyl)--->2-chloro-N-(2,2,2-trifluoroethyl)acetamide-->Benzenamine, 3-methyl-N-(2,2,2-trifluoroethyl)--->Benzenamine, 3-chloro-N-(2,2,2-trifluoroethyl)--->4-bromo-N-(2,2,2-trifluoroethyl)aniline |
