Introduction：Basic information about 2,2,6,6-Tetramethyl-4-piperidinol CAS 2403-88-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Table of Contents
- 1. 2,2,6,6-Tetramethyl-4-piperidinol Basic information
- 2. 2,2,6,6-Tetramethyl-4-piperidinol Chemical Properties
- 3. Safety Information
- 4. 2,2,6,6-Tetramethyl-4-piperidinol Usage And Synthesis
- 5. 2,2,6,6-Tetramethyl-4-piperidinol Preparation Products And Raw materials
2,2,6,6-Tetramethyl-4-piperidinol Basic information
| Product Name: | 2,2,6,6-Tetramethyl-4-piperidinol |
| Synonyms: | TAA-OL;TRIACETONEAMINO ALCOHOL;Tetramethyl piperidylol;2,2,6,6-TETRAMETHYL-4-PIPERIDINOL 99+%;Triacetoneamino Alcohol TAA-ol;Triacetonalkamine;6-Tetramethyl-4-piperidinol;4-HYDROXY-2,2,6,6-TETRAMETHYLPIPERIDINETAA-OL |
| CAS: | 2403-88-5 |
| MF: | C9H19NO |
| MW: | 157.25 |
| EINECS: | 219-291-2 |
| Product Categories: | Chemical intermediate;Aromatics;API intermediates;Heterocycles;Intermediates;Nitric Oxide Reagents;Industrial/Fine Chemicals;Nitrogen cyclic compounds;Miscellaneous;2403-88-5 |
| Mol File: | 2403-88-5.mol |
|
2,2,6,6-Tetramethyl-4-piperidinol Chemical Properties
| Melting point | 129-131 °C(lit.) |
| Boiling point | 212-215 °C(lit.) |
| density | 1.085 |
| refractive index | 1.4248 (estimate) |
| Fp | 212-215°C |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | methanol: 0.1 g/mL, clear |
| pka | 14.99±0.60(Predicted) |
| form | Crystals, Crystalline Powder and/or Chunks |
| color | White to off-white or slightly beige |
| PH | 11.2 (4g/l, H2O, 20℃) |
| Water Solubility | 130 g/L (23 ºC) |
| BRN | 105039 |
| InChI | 1S/C9H19NO/c1-8(2)5-7(11)6-9(3,4)10-8/h7,10-11H,5-6H2,1-4H3 |
| InChIKey | VDVUCLWJZJHFAV-UHFFFAOYSA-N |
| SMILES | CC1(C)CC(O)CC(C)(C)N1 |
| CAS DataBase Reference | 2403-88-5(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Piperidinol, 2,2,6,6-tetramethyl-(2403-88-5) |
| EPA Substance Registry System | 4-Piperidinol, 2,2,6,6-tetramethyl- (2403-88-5) |
Safety Information
| Hazard Codes | Xi,C |
| Risk Statements | 36/37/38-43-34 |
| Safety Statements | 26-36-45-36/37/39 |
| RIDADR | UN3259 8/PG 2 |
| WGK Germany | 1 |
| RTECS | TN7871675 |
| Hazard Note | Irritant |
| TSCA | TSCA listed |
| HazardClass | 8 |
| PackingGroup | III |
| HS Code | 29333999 |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| Hazard Classifications | Skin Corr. 1B
Skin Sens. 1 |
2,2,6,6-Tetramethyl-4-piperidinol Usage And Synthesis
| Chemical Properties | white to slightly beige crystalline powder |
| Uses | An intermediate in the preparation of Piperidinyloxy free radical derivatives. |
| Uses | 2,2,6,6-tetramethyl-4-piperidinol has been used to study the irradiation of Camptothecin (CPT) in aerated dimethylsulfoxide (DMSO) solution that leads to formation of singlet oxygen. |
| Synthesis Reference(s) | The Journal of Organic Chemistry, 37, p. 2050, 1972 DOI: 10.1021/jo00977a047 |
| Purification Methods | The piperidine crystallises from water as a hydrate and crystallises from dry ether or *C6H6 as the anhydrous base. The hydrochloride has m 282-284o (from EtOH/H2O), and the formate has m 207o(dec, from EtOH/EtOAc). [Mailey & Day J Org Chem 22 1061 1957, Beilstein 21 I 195, 21 III/IV 146, 21/1 V 159.] |
2,2,6,6-Tetramethyl-4-piperidinol Preparation Products And Raw materials
| Raw materials | 4,4'-bis(2,2,6,6-tetramethylpiperidin-4-ol)-->1,2,2,6,6-Pentamethyl-4-piperidinol-->Triacetonamine-->2,2,6,6-Tetramethyl-4-piperidone hydrochloride-->N-BUTYL TRIACETONEDIAMINE-->DIPHENYLDIAZOMETHANE-->2,6-Dimethyl-2,5-heptadien-4-one-->Butylamine |
| Preparation Products | LMI070-->4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy |
