2,4-Dimethylthiazole CAS 541-58-2
Introduction：Basic information about 2,4-Dimethylthiazole CAS 541-58-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2,4-Dimethylthiazole Basic information
| Product Name: | 2,4-Dimethylthiazole |
| Synonyms: | 2,4-METHYLTHIAZOLE;2,4-DIMETHYL-1,3-THIAZOLE;2,4-DIMETHYLTHIAZOLE;2,4-dimethyl-thiazol;2 4-DIMETHYLTHIAZOLE 95+%;2,4-Dimethylthiazole,97%;dimethylthiazole,2,4-dimethylthiazole;Thiazole, 2,4-dimethyl- |
| CAS: | 541-58-2 |
| MF: | C5H7NS |
| MW: | 113.18 |
| EINECS: | 208-786-9 |
| Product Categories: | Building Blocks;Heterocyclic Building Blocks;Alphabetical Listings;C-D;Flavors and Fragrances;thiazole Flavor;Thiazoles;Organics |
| Mol File: | 541-58-2.mol |
2,4-Dimethylthiazole Chemical Properties
| Melting point | 272 °C |
| Boiling point | 144-146 °C719 mm Hg(lit.) |
| density | 1.056 g/mL at 25 °C(lit.) |
| refractive index | n |
| Fp | 109 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| form | Liquid |
| pka | pK1:3.98 (25°C,μ=0.1) |
| color | Clear colorless to light yellow |
| Specific Gravity | 1.06 |
| Odor | at 0.10 % in dipropylene glycol. coffee tea beefy roasted barley |
| Odor Type | coffee |
| Water Solubility | Slightly soluble in water |
| BRN | 106414 |
| LogP | 0.361 (est) |
| CAS DataBase Reference | 541-58-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Thiazole, 2,4-dimethyl-(541-58-2) |
| EPA Substance Registry System | Thiazole, 2,4-dimethyl- (541-58-2) |
Safety Information
| Hazard Codes | Xi,F |
| Risk Statements | 10-36/37/38 |
| Safety Statements | 16-26-36-37/39 |
| RIDADR | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| RTECS | XJ4375000 |
| TSCA | TSCA listed |
| HazardClass | 3 |
| PackingGroup | III |
| HS Code | 29339900 |
| Chemical Properties | Colorless to light yellow liqui |
| Uses | 2,4-Dimethylthiazole is a substance used in the preparation of insects repellant. It also functions as an anesthetic for aquatic animals. 2,4-Dimethylthiazole is a flavor component of peanut oils. |
| Definition | ChEBI: 2,4-Dimethylthiazole is a member of thiazoles. |
| Synthesis Reference(s) | Synthesis, p. 696, 1976 DOI: 10.1055/s-1976-24165 |
| Synthesis | 62-55-5 598-31-2 541-58-2 GENERAL METHOD: Thioacetamide (0.75 g, 10 mmol) and bromoacetone (1.99 g, 10 mmol) were dissolved in 5 mL of DMF in a 20 mL pressure tube. The reaction mixture was sealed and heated in an oil bath at 60 °C for 1 hour. After the reaction was completed, the reaction mixture was diluted with saturated aqueous ammonium chloride solution. Subsequently, the target product 2,4-dimethylthiazole was extracted with ethyl acetate. The combined organic layers were dried with anhydrous magnesium sulfate, filtered and concentrated. Finally, the crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate) to afford 2,4-dimethylthiazole in 99% yield as a white solid. |
| References | [1] Tetrahedron, 2013, vol. 69, # 51, p. 10990 - 10995 |
2,4-Dimethylthiazole Preparation Products And Raw materials
| Raw materials | Phosphorus pentasulfide-->Acetamide-->Chloroacetone-->2,2-dichloropropane-->Thiazole, 4,5-dihydro-2,4-dimethyl--->Dimethyl Oxazole-->2-Propanone, 1-mercapto--->4-CHLOROMETHYL-2-METHYLTHIAZOLE HYDROCHLORIDE-->CHLORIDE STANDARD-->4-Methylthiazole-->LITHIUM TETRACHLOROAURATE(III)-->Hydrochloric acid-->Acetonitrile-->Dimethyl sulfate-->Thioacetamide |
| Preparation Products | Trimethyl thiazole-->4-METHYL-2-THIAZOLECARBOXALDEHYDE 97-->2-Ethyl-4-methyl thiazole |
