2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]ac

Introduction：Basic information about 2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]ac, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid Basic information

• Product Name: 2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid
• Synonyms: (+)-[(2s,6r)-6-[[(s)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid;2-[(2s)-6-[[(1s)-1-ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid;TEMOCAPRIL;(2E,5E)-2,6-bis(butylamino)-4-hepta-2,5-dienone;TEMOCAPRILDISCONTINUED SEE T017301;Temocapil;(2S,6R)-6-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic Aci;1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, (2S,6R)- (9CI)
• CAS: 111902-57-9
• MF: C23H28N2O5S2
• MW: 476.61
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 111902-57-9.mol

2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid Chemical Properties

• Melting point: 1680C
• alpha: 23 +40° (c = 1.1 in DMF)
• Boiling point: 717.4±60.0 °C(Predicted)
• density: 1.33±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• pka: 3.73±0.10(Predicted)
• form: Powder
• color: Crystalline
• CAS DataBase Reference: 111902-57-9(CAS DataBase Reference)

2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid Usage And Synthesis

Chemical Properties

Crystalline Powder

Uses

Angiotensin-converting enzyme (ACE) inhibitor. Hydrolyzed in vivo to the active diacid metabolite.

Definition

ChEBI: Temocapril is a dipeptide.

in vivo

Temocapril (10 mg/kg; p.o.; 21 d) enhances cardiomyocyte thioredoxin expression and ameliorates autoimmune myocarditis^[3].
Temocapril (30 mg/kg; p.o.; daily; for 4 weeks) suppresses Angiotensin I-induced hypertension, plasma and renal ACE activity, but fails to reduce the level of Ang II in the kidney^[4].

• Animal Model: Experimental autoimmune myocarditis (EAM) rat model^[3]
• Dosage: 10 mg/kg
• Administration: Oral gavage; administration by water; 21 days
• Result: Ameliorated EAM and prevented cellular proteins from oxidation. Enhanced cardiomyocyte redox regulatory protein TRX expression.

• Animal Model: Male Sprague Dawley rats^[4]
• Dosage: 30 mg/kg
• Administration: Oral gavage, daily, for 4 weeks
• Result: Suppressed the blood pressure elevation induced by Ang I.