Introduction：Basic information about 2-[2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHANOL CAS 57671-28-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2-[2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHANOL Basic information
| Product Name: | 2-[2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHANOL |
| Synonyms: | PENTAETHYLENE GLYCOL MONOBENZYL ETHER;2-[2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHANOL;BnO-PEG5-OH;1-phenyl-2,5,8,11,14-pentaoxahexadecan-16-ol;Benzyl-PEG6-alcohol;2-[2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHA;CAS_57671-28-0;PentaethyleneGlycolMonobenzylEther> |
| CAS: | 57671-28-0 |
| MF: | C17H28O6 |
| MW: | 328.4 |
| EINECS: | |
| Product Categories: | Ethylene Glycols & Monofunctional Ethylene Glycols;Monofunctional Ethylene Glycols |
| Mol File: | 57671-28-0.mol |
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2-[2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHANOL Chemical Properties
| Boiling point | 437.2±40.0 °C(Predicted) |
| density | 1.10 |
| refractive index | 1.4950 to 1.4990 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in DMSO, DCM, DMF |
| form | clear liquid |
| pka | 14.36±0.10(Predicted) |
| color | White to Yellow to Green |
| InChI | InChI=1S/C17H28O6/c18-6-7-19-8-9-20-10-11-21-12-13-22-14-15-23-16-17-4-2-1-3-5-17/h1-5,18H,6-16H2 |
| InChIKey | UMUSOTNGYAALST-UHFFFAOYSA-N |
| SMILES | C(C1=CC=CC=C1)OCCOCCOCCOCCOCCO |
Safety Information
2-[2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHANOL Usage And Synthesis
| Description | Benzyl-PEG6-alcohol is a PEG linker with a benzyl protecting group and a primary alcohol. The benzyl protecting group can be removed under acidic conditions. The primary alcohol can react to further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. |
| Uses | BnO-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. |
| IC 50 | PEGs |
| References | [1] Girardini M, et al. Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs. Bioorg Med Chem. 2019 Jun 15;27(12):2466-2479. DOI:10.1016/j.bmc.2019.02.048 |
2-[2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHANOL Preparation Products And Raw materials
| Preparation Products | 3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxaoctatriacontane-1,38-diol-->Amino-PEG5-alcohol |
