Introduction：Basic information about 2-Amino-1-pyrroline Hydrochloride CAS 7544-75-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2-Amino-1-pyrroline Hydrochloride Basic information
| Product Name: | 2-Amino-1-pyrroline Hydrochloride |
| Synonyms: | 3,4-Dihydro-2H-pyrrol-5-aMine hydrochloride;2-AMinopyrrolidine HCl;2-AMINO-1-PYRROLINE HYDROCHLORIDE;4,5-Dihydro-3H-pyrrol-2-ylamine hydrochloride;2H-Pyrrol-5-amine, 3,4-dihydro-, hydrochloride (1:1);2-amino-4,5-dihydro-3H-pyrrole HCl salt;2H-Pyrrol-5-amine, 3,4-dihydro-, monohydrochloride;2-Aminopyrrolidine hydrochloride |
| CAS: | 7544-75-4 |
| MF: | C4H9ClN2 |
| MW: | 120.58066 |
| EINECS: | |
| Product Categories: | chemical;1 |
| Mol File: | 7544-75-4.mol |
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2-Amino-1-pyrroline Hydrochloride Chemical Properties
| Melting point | 171.0 to 175.0 °C |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | powder to crystal |
| color | White to Almost white |
| InChI | InChI=1S/C4H8N2.ClH/c5-4-2-1-3-6-4;/h1-3H2,(H2,5,6);1H |
| InChIKey | JEBHLIYFPKISBI-UHFFFAOYSA-N |
| SMILES | C1(N)=NCCC1.Cl |
Safety Information
| RIDADR | UN 1993 3/PG III |
| WGK Germany | WGK 3 |
| HazardClass | 3 |
| PackingGroup | III |
| HS Code | 2933998090 |
| Storage Class | 11 - Combustible Solids |
2-Amino-1-pyrroline Hydrochloride Usage And Synthesis
| Uses | 2-Aminopyrrolidine hydrochloride is a heterocyclic organic compound that can be used as a pharmaceutical intermediate. |
| Synthesis | In a 250 mL bottomed flask, ammonia was bubbled into ethanol (80 mL) that was cooled to -78° C. for 45 min. The saturated solution that was obtained was transferred to a Parr autoclave, which contained 4-chlorobutanenitrile (60 g, 580 mmol). The mixture was stirred and heated to 120° C for 16 hr. The reaction mixture was cooled and transferred to a round-bottomed flask. The solvent was removed under reduced pressure to afford a yellow solid, which was washed with diethyl ether and dried under a high vacuum to afford an off-white solid 2-Amino-1-pyrroline Hydrochloride, 19.5 g, 232 mmol, 40percent yield. 1H NMR (DMSO-d6) δ 9.22 (br s, 1H), 8.93 (br s, 1H), 7.60 (br s, 1H), 3.52 (d, J=7.2 Hz, 2H), 2.76 (d. J=8.0 Hz, 2H), 2.08-1.96 (m, 2H). |
| References | [1] Patent: US2014/148461, 2014, A1. Location in patent: Paragraph 0354-0355 |
2-Amino-1-pyrroline Hydrochloride Preparation Products And Raw materials
| Raw materials | 5-METHOXY-3,4-DIHYDRO-2H-PYRROLE-->4-Chlorobutyronitrile-->Ammonia-->Ethanol |
