Introduction：Basic information about 2-Amino-4-chlorobenzoic acid CAS 89-77-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2-Amino-4-chlorobenzoic acid Basic information
| Product Name: | 2-Amino-4-chlorobenzoic acid |
| Synonyms: | 4-CHLORO-2-AMINOBENZOIC ACID;2,4-ACBA;3-AMINO-4-CARBOXY-1-CHLOROBENZENE;2-AMINO-4-CHLOROBENZOIC ACID;2-CARBOXY-5-CHLOROANILINE;4-chloroanthranil acid;p-Chloro-o-Amino Benzoic Acid;4-ChloroanthranilicAcid98% |
| CAS: | 89-77-0 |
| MF: | C7H6ClNO2 |
| MW: | 171.58 |
| EINECS: | 201-938-5 |
| Product Categories: | API Intermediate;FINE Chemical & INTERMEDIATES;Amines;blocks;Carboxes;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid series;API;bc0001;89-77-0 |
| Mol File: | 89-77-0.mol |
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2-Amino-4-chlorobenzoic acid Chemical Properties
| Melting point | 231-233 °C (lit.) |
| Boiling point | 250°C (rough estimate) |
| density | 1.3246 (rough estimate) |
| refractive index | 1.5560 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | almost transparency in 1mol/L NaOH |
| pka | 4.71±0.10(Predicted) |
| form | Powder |
| color | Beige to light brown |
| Water Solubility | slightly soluble |
| BRN | 743349 |
| Major Application | peptide synthesis |
| InChI | InChI=1S/C7H6ClNO2/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3H,9H2,(H,10,11) |
| InChIKey | JYYLQSCZISREGY-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C(Cl)C=C1N |
| CAS DataBase Reference | 89-77-0(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Amino-4-chlorobenzoic acid(89-77-0) |
Safety Information
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-20/21/22 |
| Safety Statements | 26-36-37/39 |
| WGK Germany | 3 |
| RTECS | DG1570000 |
| HS Code | 29163990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
2-Amino-4-chlorobenzoic acid Usage And Synthesis
| Chemical Properties | off-white powder |
| Uses | 2-Amino-4-chlorobenzoic Acid is used in the preparation of quinazolinone derivatives observed to be useful in the treatment of Alzheimer’s disease. Also it aids in the synthesis of non-nucleoside, thumb pocket 2 HCV NS5B polymerase inhibitors used in Hepatitis C therapy. |
| Definition | ChEBI: 2-Amino-4-chlorobenzoic acid is an aminobenzoic acid. |
| reaction suitability | reaction type: solution phase peptide synthesis |
2-Amino-4-chlorobenzoic acid Preparation Products And Raw materials
| Preparation Products | 3',4'-DICHLOROACETOPHENONE-->1-Acetyl-5-broMo-6-chloro-1H-indol-3-yl acetate-->USP7-IN-1-->N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-aminoquinazolin-4-aMine-->4,7-Dichloroquinazoline-->7-CHLORO-4-QUINAZOLINOL-->6-Amino-11-chloronaphth[2,3-c]acridine-5,8,14(13H)-trione-->7-Chloro-3-hydroxybenzo[d][1,2,3]triazin-4(3H)-one-->7-chloro-3-(2-methylphenyl)-2-sulfanyl-3,4-dihydroquinazolin-4-one-->2-Chloro-9,10-dihydro-9,10-[1,2]benzenoanthracene-->5-Bromo-4-chloro-2-iodo-benzoic acid-->7-Chloro-2-(trifluoromethyl)quinazolin-4(1H)-one-->3-AMINO-7-CHLORO-2-METHYLQUINAZOLIN-4(3H)-ONE-->7-Chloro-2-chloroMethyl-1H-quinazolin-4-one |
