2-AMINO-5-METHYLBENZAMIDE CAS 40545-33-3
Introduction：Basic information about 2-AMINO-5-METHYLBENZAMIDE CAS 40545-33-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2-AMINO-5-METHYLBENZAMIDE Basic information
| Product Name: | 2-AMINO-5-METHYLBENZAMIDE |
| Synonyms: | Benzamide, 2-amino-5-methyl- (9CI);Benzamide, 2-amino-5-methyl-;2-AMINO-5-METHYLBENZAMIDE;2-AMINO-5-METHYLBENZAMIDE ISO 9001：2015 REACH |
| CAS: | 40545-33-3 |
| MF: | C8H10N2O |
| MW: | 150.18 |
| EINECS: | |
| Product Categories: | AMIDE;AMINEPRIMARY |
| Mol File: | 40545-33-3.mol |
2-AMINO-5-METHYLBENZAMIDE Chemical Properties
| Melting point | 178-180°C |
| Boiling point | 265.7±28.0 °C(Predicted) |
| density | 1.185±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | solid |
| pka | 15.88±0.50(Predicted) |
| Appearance | Off-white to light yellow Solid |
| InChI | 1S/C8H10N2O/c1-5-2-3-7(9)6(4-5)8(10)11/h2-4H,9H2,1H3,(H2,10,11) |
| InChIKey | LLSGVPKOCZZLTF-UHFFFAOYSA-N |
| SMILES | Cc1ccc(N)c(c1)C(N)=O |
| CAS DataBase Reference | 40545-33-3(CAS DataBase Reference) |
Safety Information
| Risk Statements | 36/37/38-36 |
| Safety Statements | 26-36/37/39 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 |
| Synthesis | 4315-12-2 40545-33-3 Step 2: 5-Methyl-2-nitrobenzamide (15.0 g, 83.3 mmol) was dissolved in methanol (300 mL) and 10% palladium carbon catalyst (2.50 g) was added. The reaction was stirred for 12 hours under hydrogen atmosphere (1 atmosphere) and room temperature. After completion of the reaction, the insoluble material was removed by filtration and the filtrate was concentrated to afford 2-amino-5-methylbenzamide (12.4 g, 99% yield) in white powder form. |
| References | [1] Patent: EP1953148, 2008, A1. Location in patent: Page/Page column 130 [2] Patent: US2015/329556, 2015, A1. Location in patent: Paragraph 1532 [3] Journal of Medicinal Chemistry, 1992, vol. 35, # 14, p. 2626 - 2630 [4] Patent: US5234925, 1993, A [5] European Journal of Medicinal Chemistry, 2011, vol. 46, # 7, p. 2786 - 2796 |
2-AMINO-5-METHYLBENZAMIDE Preparation Products And Raw materials
| Raw materials | 5-Methylisatin-->5-Methyl-2-nitrobenzoic acid-->5-methyl-2-nitrobenzoyl chloride-->5-METHYL-2-NITROBENZAMIDE-->5-METHYL-2-NITROBENZONITRILE-->6-METHYL ISATINIC ANHYDRIDE-->2-Amino-5-Methyl-Benzonitrile-->2-Amino-5-methylbenzoic acid-->1,1'-Carbonyldiimidazole-->m-Tolunitrile-->Oxalyl chloride |
