Introduction：Basic information about 2-Aminoadenosine CAS 2096-10-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2-Aminoadenosine Basic information
| Product Name: | 2-Aminoadenosine |
| Synonyms: | 2-AMINE ADENOSINE;2-AMINOADENOSINE;2,6-DIAMINOPURINE RIBOSIDE;2-AMINOADENOSINE HPLC98+%;Aminoadenosine;2-NH2-A;Adenosine, 2-amino-;Regadenoson Impurity 23 |
| CAS: | 2096-10-8 |
| MF: | C10H14N6O4 |
| MW: | 282.26 |
| EINECS: | 606-677-4 |
| Product Categories: | Amines;Heterocycles;Nucleotides and Nucleosides;Nucleic acids;Bases & Related Reagents;Nucleotides;2096-10-8;Nucleosides-Ribonucleosides |
| Mol File: | 2096-10-8.mol |
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2-Aminoadenosine Chemical Properties
| Melting point | 241-243°C (dec.) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Aqueous Acid (Slightly, Heated, Sonicated), DMSO (Slightly, Sonicated), Ethanol |
| pKa | 13.10±0.70(Predicted) |
| Boiling point | 798.5±70.0 °C(Predicted) |
| density | 2.25±0.1 g/cm3(Predicted) |
| form | Powder |
| color | White to Off-White |
| InChI | InChI=1S/C10H14N6O4/c11-7-4-8(15-10(12)14-7)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H4,11,12,14,15)/t3-,5-,6-,9-/m1/s1 |
| InChIKey | ZDTFMPXQUSBYRL-UUOKFMHZSA-N |
| SMILES | OC[C@H]1O[C@@H](N2C3C(=C(N=C(N)N=3)N)N=C2)[C@H](O)[C@@H]1O |
| CAS DataBase Reference | 2096-10-8(CAS DataBase Reference) |
Safety Information
| Safety Statements | 24/25 |
| HS Code | 29389090 |
2-Aminoadenosine Usage And Synthesis
| Description | 2-Aminoadenosine is a known analogue of adenosine that engages in three hydrogen bonds of the W-C type, adding considerable stability to the double helix. |
| Chemical Properties | White Powder |
| Uses | 2-Aminoadenosine is a nucleoside analog as inhibitor or substrate of adenosine kinase from M. tuberculosis. It is also used to synthesize 2′-O-methyl and 3′-O-methyl Guanosine. |
| Definition | ChEBI: 2-Aminoadenosine is a purine nucleoside. |
| Synthesis | The synthesis of 2-aminoadenosine (2-AA): Assays were performed in 5 and 10% of aprotic dipolar co-solvents, at 60°C, twelve units/ml cell lysate were added to 150 ml of a solution kept thermostatically at 60 °C, and having the following composition of substrate solutions: 15mM Uridine/2 ' -Deoxyuridine,5 mM 2,6-Diaminopurine, and 30 mM potassium phosphate buffer, pH 7. After 5 hours, the reaction mixture was filtered by centrifugation at 2000 x g for 30 min, at 4°C, through an Amicon ultra-4 Centrifugal Filter Devices (Millipore, Bedford, MA) with a 3000-Da cutoff, and the filtrate was recovered.
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| References | Pyrazolo[3,4-d]pyrimidine ribonucleosides related to 2-aminoadenosine and isoguanosine: synthesis, deamination and tautomerism. DOI: 10.1039/B708736E
An Efficient Process for Synthesis of 2′-O-methyl and 3′-O-methyl Guanosine from 2-aminoadenosine Using Diazomethane and the Catalyst Stannous Chloride. DOI: 10.1080/15257770500544529 |
2-Aminoadenosine Preparation Products And Raw materials
| Preparation Products | 2-AMINO-2'-O-METHYLADENOSINE-->2-AMino-8-broMoadenosine |
