Introduction：Basic information about 2'-Deoxyinosine CAS 890-38-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2'-Deoxyinosine Basic information
| Product Name: | 2'-Deoxyinosine |
| Synonyms: | Didanosine EP Impurity C;Didanosine Impurity Ⅲ:2'-Deoxyinosine;Didanosine Impurity 3（Didanosine EP Impurity C）;2'-Deoxyinosine(Di);DEOXYINOSINE, 2'-(RG);9-[(2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)oxolan-2-yl]-9H-purin-6-ol;9-((2R,4S,5R)-4-Hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;1,9-Dihydro-9-(2'-deoxy-β-D-ribofuranosyl)-6H-purin-6-one |
| CAS: | 890-38-0 |
| MF: | C10H12N4O4 |
| MW: | 252.23 |
| EINECS: | 212-964-1 |
| Product Categories: | Bases & Related Reagents;Heterocycles;Impurities;Inhibitors;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Heterocycles, Impurities, Inhibitors, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals;Pyridines, Pyrimidines, Purines and Pteredines;Pharmaceutical Raw Materials;Biochemistry;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents |
| Mol File: | 890-38-0.mol |
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2'-Deoxyinosine Chemical Properties
| Melting point | 250 °C |
| alpha | 21 º (c=1, H2O 22 ºC) |
| Boiling point | 395.4°C (rough estimate) |
| density | 1.3402 (rough estimate) |
| refractive index | -16 ° (C=1, H2O) |
| storage temp. | -20°C |
| solubility | DMSO (Slightly), Water (Slightly) |
| pka | 8.92±0.70(Predicted) |
| form | Powder |
| color | White to Off-white |
| biological source | synthetic (organic) |
| Water Solubility | 8.33g/L(25.02 ºC) |
| BRN | 33517 |
| InChI | InChI=1S/C10H12N4O4/c15-2-6-5(16)1-7(18-6)14-4-13-8-9(14)11-3-12-10(8)17/h3-7,15-16H,1-2H2,(H,11,12,17)/t5-,6+,7+/m0/s1 |
| InChIKey | VGONTNSXDCQUGY-RRKCRQDMSA-N |
| SMILES | OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)O)N=C2)C[C@@H]1O |
| CAS DataBase Reference | 890-38-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Inosine, 2'-deoxy-(890-38-0) |
Safety Information
| Hazard Codes | Xn,Xi |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 24/25-37/39-36-26 |
| WGK Germany | 3 |
| F | 10-23 |
| HS Code | 29349990 |
| Storage Class | 11 - Combustible Solids |
2'-Deoxyinosine Usage And Synthesis
| Chemical Properties | Crystalline |
| Uses | An Inosine (I661000) analog with hypotensive activity. An impurity of the antiviral drug 2’,3’-Dideoxyinosine (D440950). |
| Uses | 2′-Deoxyinosine has been used in the quantification of nucleoside forms of DNA lesion in a single DNA sample by liquid chromatography tandem mass spectrometry (LC-MS/MS). It has also been used as a standard for high performance liquid chromatography analysis. |
| Definition | ChEBI: 2'-deoxyinosine is a purine 2'-deoxyribonucleoside that is inosine in which the hydroxy group at position 2' is replaced by a hydrogen. It has a role as a Saccharomyces cerevisiae metabolite, a human metabolite, a plant metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a purines 2'-deoxy-D-ribonucleoside and a purine 2'-deoxyribonucleoside. It is functionally related to an inosine. |
| Biochem/physiol Actions | 2′-Deoxyinosine is a nucleoside form of hypoxanthine. It is a DNA damage product resulting from the impairment of DNA by reactive nitrogen species. 2′-deoxyinosine is formed from nitrosative deamination by N2O3. |
| Purification Methods | 2'-Deoxyinosine [890-38-0] M 252.2, m 206o(dec), 218-220o(dec), [ ] D25 -21o (c 2, N ] D -21o (c 1, H 2O), pKEst(1) ~ 8.9, pKEst(2) ~ 12.4. Purify 2'-deoxyinosine by recrystallisation from H2O. [Brown & Lythgoe J Chem Soc 1990 1950, UV: MacNutt Biochem J 50 384 1952, Beilstein 26 III/IV 2086.] |
2'-Deoxyinosine Preparation Products And Raw materials
| Preparation Products | N-(9 beta-D-2'-deoxyribofuranosylpurin-6-yl)glycinamide |
