2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl CAS 657408-07-6
2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Basic informationUses Reactions
| Product Name: | 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl |
| Synonyms: | 98% SPhos;2-Dicyclohexylphosphino-2',6'-diMethoxy-1,1'-biphenyl ,98%;2-Dicyclohexylphosphino-2', 6-diMethoxybihenyl;2-DicyclohexylphosphiNA-2',6'-diMethoxybiphenyl;SPhos 97%;2-Dicyclohexylphosphino-2',6'-diMethoxybiphenyl, 6'-diMethoxybiphenyl;2 - dicyclohexyl phosphine - 2 ', 6 '- diMethoxy - 1, 1' - two PCB;2-Dicyclohexylphosphino-2',6'- |
| CAS: | 657408-07-6 |
| MF: | C26H35O2P |
| MW: | 410.53 |
| EINECS: | 613-838-2 |
| Product Categories: | Phosphines;Achiral Phosphine;Aryl Phosphine;Buchwald Ligands Series;Buchwald Ligands&Precatalysts;bc0001 |
| Mol File: | 657408-07-6.mol |
2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Chemical Properties
| Melting point | 164-166°C |
| Boiling point | 513.3±40.0 °C(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | soluble in Chloroform |
| form | crystal |
| color | white |
| Sensitive | Air Sensitive |
| InChI | InChI=1S/C26H35O2P/c1-27-23-17-11-18-24(28-2)26(23)22-16-9-10-19-25(22)29(20-12-5-3-6-13-20)21-14-7-4-8-15-21/h9-11,16-21H,3-8,12-15H2,1-2H3 |
| InChIKey | VNFWTIYUKDMAOP-UHFFFAOYSA-N |
| SMILES | P(C1CCCCC1)(C1CCCCC1)C1=CC=CC=C1C1=C(OC)C=CC=C1OC |
Safety Information
| Hazard Codes | Xn |
| Risk Statements | 40 |
| Safety Statements | 24/25-36/37 |
| WGK Germany | 3 |
| TSCA | No |
| HS Code | 2931499090 |
| Storage Class | 11 - Combustible Solids |
| Uses | SPhos [2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions. SPhos may be used as a ligand in the following processes: • Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between Boc-protected aminomethyltrifluoroborate and aryl chlorides or hetaryl chlorides to form the corresponding aminomethylarenes.• Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between 4-methyl-substituted piperidinylzinc reagent and different aryl or heteroaryl iodides to form various substituted piperidines.• Intramolecular Suzuki-Miyaura coupling to form the 18-membered macrocyclic ring during the multi-step synthesis of riccardin C. Utilized in conjunction with palladium to form a highly active catalyst for C-N bond formation. Highly universal ligand for Suzuki-Miyaura coupling; aryl chlorides, hindered biaryls, heterobiaryls. |
| Reactions |
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| Chemical Properties | White solid |
| Uses | S-Phos is a catalyst that is used in the preparation of thiadiazoles as DGAT1 inhibitors with potential in metabolic diseases treatment. |
| Uses | suzuki reaction |
| General Description | SPhos [2-Dicyclohexylphosphino-2′, 6′-dimethoxybiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions. |
| reaction suitability | reagent type: catalyst reaction type: Cross Couplings |
| Synthesis | 694-80-4 151-10-0 16523-54-9 657408-07-6 To a solution of 1,3-dimethoxybenzene (2 mL, 15.30 mmol) in anhydrous THF (35 mL) was slowly added n-butyllithium (nBuLi, 6.2 mL, 15.50 mmol) through a dropping funnel over 5 min at 0 °C. The reaction mixture was stirred at room temperature for 3.5 h. After stirring, 2-bromochlorobenzene (1.6 mL, 13.70 mmol) was added slowly dropwise through a syringe at 0 °C for 30 min. After stirring for 15 min, the reaction mixture was cooled to -78 °C and n-butyllithium (6.20 mL, 15.50 mmol) was again added slowly through a dropping funnel over 5 min. 30 min later, chlorodicyclohexylphosphine (3.03 mL, 13.70 mmol) was added. The reaction mixture was kept at -78 °C for 1 h, during which rapid mechanical stirring was performed. Subsequently, the reaction mixture was warmed to room temperature and the resulting precipitate was filtered through a silica gel sintered disc covered with a cellulose acetate layer and washed with 600 mL of ethyl acetate. The filtrate was concentrated by rotary evaporation and the resulting orange oil was recrystallized in acetone to give white crystalline S-Phos ligand in 36% yield (1.22 g, 2.97 mmol). Melting point: 163-165 °C (literature value 162.0-162.5 °C); Thin layer chromatography (TLC) conditions: ethyl acetate/cyclohexane (10/90), Rf = 0.65; 1H-NMR (CDCl3): δ = 0.99-1.26 (m, 10H, H(Cy)), 1.60-1.77 (m, 12H, H(Cy)), and 3.67 (s, 6H, Me), 6.58 (d, 2H, J = 8.2 Hz, H3' and H5'), 7.15-7.18 (m, 1H, H(Ar)), 7.18-7.42 (m, 3H, H(Ar)), 7.57 (d, 1H, J = 7.4 Hz, H(Ar)) ppm; 13C-NMR (CDCl3): δ = 26.5, 27.3, 27.4, 27.6, 29.0, 29.1, 29.8, 30.1, 33.8, 34.0 (C(Cy)), 55.3 (Cb), 103.1 (Ca), 126.2, 128.2, 128.8 (C3', C4', C5'), 130.9, 131.00, 132.4. 135.8 (C3, C4, C5, C6), 135.8, 136.1, 142.7, 143.1, 157.4 (C2', C6') ppm; IR (KBr): υ = 3000, 2923, 2851, 1588, 1471, 1442, 1428, 1108 cm-1. |
| References | [1] Patent: US2011/184059, 2011, A1. Location in patent: Page/Page column 9 |
2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Preparation Products And Raw materials
| Raw materials | Ethyl acetate-->Tetrahydrofuran-->PETROLEUM ETHER-->n-Butyllithium-->Magnesium-->1,3-Dimethoxybenzene-->1,2-Dibromobenzene-->Dicyclohexylchlorophosphine-->2-Bromochlorobenzene |
| Preparation Products | Boronic acid, B-(6-phenyl-4-dibenzofuranyl)--->SPhos Pd G1, Methyl t-Butyl Ether Adduct |
