2-Pyridinecarboxaldehyde CAS 1121-60-4
Introduction：Basic information about 2-Pyridinecarboxaldehyde CAS 1121-60-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2-Pyridinecarboxaldehyde Basic information
| Product Name: | 2-Pyridinecarboxaldehyde |
| Synonyms: | AKOS BBS-00003192;2-FORMYLPYRIDINE;2-PA;2-PICOLINIC ALDEHYDE;2-PYRIDINECARBALDEHYDE;2-PYRIDINECARBOXALDEHYDE;TIMTEC-BB SBB004358;PYRIDINE-2-CARBOXALDEHYDE |
| CAS: | 1121-60-4 |
| MF: | C6H5NO |
| MW: | 107.11 |
| EINECS: | 214-333-6 |
| Product Categories: | Heterocycle-Pyridine series;Building Blocks;C1 to C6;C6;Carbonyl Compounds;Chemical Synthesis;Pyridine series;Aldehydes;Pyridines;Pyridines derivates;Heterocyclic Compounds;Heterocyclic Building Blocks;Organic Building Blocks;pharm intermediate;Pyridine;bc0001;1121-60-4 |
| Mol File: | 1121-60-4.mol |
2-Pyridinecarboxaldehyde Chemical Properties
| Melting point | -21--22°C |
| Boiling point | 181 °C(lit.) |
| density | 1.126 g/mL at 25 °C(lit.) |
| vapor pressure | 73Pa at 20℃ |
| refractive index | n |
| Fp | 130 °F |
| storage temp. | 2-8°C |
| pka | 3.8(at 20℃) |
| form | liquid (strong colored) |
| color | Clear yellow to yellow-brown |
| PH | 6.5 (111g/l, H2O, 20℃) |
| Water Solubility | miscible |
| Sensitive | Air Sensitive |
| BRN | 105341 |
| InChI | 1S/C6H5NO/c8-5-6-3-1-2-4-7-6/h1-5H |
| InChIKey | CSDSSGBPEUDDEE-UHFFFAOYSA-N |
| SMILES | [H]C(=O)c1ccccn1 |
| LogP | 0.714 at 20.5℃ |
| CAS DataBase Reference | 1121-60-4(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Pyridinecarboxaldehyde(1121-60-4) |
| EPA Substance Registry System | 2-Pyridinecarboxaldehyde (1121-60-4) |
Safety Information
| Hazard Codes | Xn,Xi,N,T,F |
| Risk Statements | 10-22-36/37/38-51/53-46-43-34-23-52 |
| Safety Statements | 7-26-36-61-53-45-36/37/39-29-16-36/37 |
| RIDADR | UN 1989 3/PG 3 |
| WGK Germany | 3 |
| F | 8-10-23 |
| Hazard Note | Irritant/Keep Cold/Air Sensitive |
| TSCA | TSCA listed |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29333999 |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
| Hazard Classifications | Acute Tox. 2 Inhalation Acute Tox. 4 Oral Eye Dam. 1 Skin Corr. 1B Skin Sens. 1 |
| Chemical Properties | Yellow liquid |
| Uses | 2-Pyridinecarboxaldehyde has been used:
It can also be combined with thiosemicarbazide to form 2-pyridinecarboxaldehyde thiosemicarbazone ligand (L) which can further complex with Ni(II) and Cu(II) salts (MX) to form [M(L)2X2] complexes. |
| Definition | ChEBI: 2-Pyridinecarboxaldehyde is a pyridinecarbaldehyde that is pyridine in which the hydrogen at position 2 is replaced by a formyl group. |
| Synthesis Reference(s) | Synthetic Communications, 23, p. 1775, 1993 DOI: 10.1080/00397919308011276 |
| Purification Methods | Purification is achieved by bubbling sulfur dioxide into a solution of 50g of the aldehyde in 250mL of boiled water, under nitrogen, at 0o, until precipitation is complete. The bisulfite addition compound is filtered off rapidly and, after washing with a little water, is refluxed in 17% HCl (200mL) under nitrogen until a clear solution is obtained. Neutralisation with NaHCO3 and extraction with ether separated the aldehyde which is recovered by drying the extract, then distilling twice, under nitrogen. [Kyte et al. J Chem Soc 4454 1960, Beilstein 21 I 287, 21 III/IV 3495, 21/7 V 293.] |
2-Pyridinecarboxaldehyde Preparation Products And Raw materials
| Raw materials | Hydrochloric acid-->Methanol-->Diethyl ether-->Tetrahydrofuran-->Dichloromethane-->N,N-Dimethylformamide-->PETROLEUM ETHER-->Toluene-->Sodium sulfate-->Sodium chloride-->Acetone-->n-Butyllithium-->Pyridine-->Chromium(VI) oxide-->2-Picoline-->acetonitrile-->2-Bromopyridine |
| Preparation Products | PYRIDIN-2-YLMETHYL-HYDRAZINE-->3-PYRIDIN-2-YL-PROPIONIC ACID H2SO4-->2-(2-Pyridyl)benzoxazole |
