3',5-DIHYDROXY-4',6,7-TRIMETHOXYFLAVONE CAS 855-96-9

Introduction：Basic information about 3',5-DIHYDROXY-4',6,7-TRIMETHOXYFLAVONE CAS 855-96-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

3',5-DIHYDROXY-4',6,7-TRIMETHOXYFLAVONE Basic information

• Product Name: 3',5-DIHYDROXY-4',6,7-TRIMETHOXYFLAVONE
• Synonyms: 5-hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-6,7-dimethoxy-chromen-4-one;5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-6,7-dimethoxychromen-4-one;5-hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-6,7-dimethoxy-chromone;EUPATORIN(SH);Bulk Inquiry;5-Hydroxy-2-(3-hydroxy-4-Methoxyphenyl)-6,7-diMethoxy-4H-chroMen-4-one;6-Methoxyluteolin 4′,7-dimethyl ether;NSC 106402
• CAS: 855-96-9
• MF: C18H16O7
• MW: 344.32
• EINECS: 663-133-9
• Product Categories: Penta-substituted Flavones
• Mol File: 855-96-9.mol

3',5-DIHYDROXY-4',6,7-TRIMETHOXYFLAVONE Chemical Properties

• Melting point: 194-196°C
• Boiling point: 587.0±50.0 °C(Predicted)
• density: 1.387±0.06 g/cm3(Predicted)
• storage temp.: room temp
• solubility: DMSO: >10mg/mL
• form: powder
• pka: 6.31±0.40(Predicted)
• color: white to beige
• Water Solubility: Insoluble in water. Soluble in chloroform and methanol.
• Merck: 14,3901
• BRN: 1355109
• InChI: 1S/C18H16O7/c1-22-12-5-4-9(6-10(12)19)13-7-11(20)16-14(25-13)8-15(23-2)18(24-3)17(16)21/h4-8,19,21H,1-3H3
• InChIKey: KLAOKWJLUQKWIF-UHFFFAOYSA-N
• SMILES: COc1ccc(cc1O)C2=CC(=O)c3c(O)c(OC)c(OC)cc3O2
• LogP: 2.960 (est)
• CAS DataBase Reference: 855-96-9(CAS DataBase Reference)

Safety Information

• Hazard Codes: T
• Risk Statements: 36/37/38-25
• Safety Statements: 26-36-45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 1
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Oral

3',5-DIHYDROXY-4',6,7-TRIMETHOXYFLAVONE Usage And Synthesis

Chemical Properties

Yellow Solid

Uses

3',5-Dihydroxy-4',6,7-trimethoxyflavone is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

Uses

Eupatorin is a flavanoid with antiproliferative activity in cells expressing the CYP1 family. Eupatorin also displays antioxidant and anti-inflammatory activity.

Definition

ChEBI: Eupatorin is a trimethoxyflavone that is 6-hydroxyluteolin in which the phenolic hydogens at positions 4', 6 and 7 have been replaced by methyl groups. It has a role as a Brassica napus metabolite, an apoptosis inducer, a vasodilator agent, a calcium channel blocker, an anti-inflammatory agent, a P450 inhibitor and an antineoplastic agent. It is a dihydroxyflavone, a trimethoxyflavone and a polyphenol. It is functionally related to a 6-hydroxyluteolin.

Biological Activity

Eupatorin acts as an antiproliferative in cells expressing the CYP1A- family. It induces G2/M block follow by apoptosis in cells expressing the CYP1A- family. It also functions as an anti-inflammatory.