3,5-DIHYDROXY-7-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE CAS 15486-33-6

Introduction：Basic information about 3,5-DIHYDROXY-7-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE CAS 15486-33-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

3,5-DIHYDROXY-7-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE Basic information

• Product Name: 3,5-DIHYDROXY-7-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE
• Synonyms: KAEMPFEROL-7,4'-DIMETHYL ETHER;3,5-DIHYDROXY-7,4'-DIMETHOXYFLAVONE;3,5-DIHYDROXY-7-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE;3,5-dihydroxy-7-methoxy-2-(4-methoxyphenyl)-4-benzopyrone;3,5-Dihydroxy-7-methoxy-2-(4-methoxy-phenyl)-;2-(4-Methoxyphenyl)-3,5-dihydroxy-7-methoxy-4H-1-benzopyran-4-one;4'-O,7-O-Dimethylkaempferol;Kaempferol 4',7-dimethyl ether
• CAS: 15486-33-6
• MF: C17H14O6
• MW: 314.29
• EINECS: 239-513-1
• Product Categories: Flavanols
• Mol File: 15486-33-6.mol

3,5-DIHYDROXY-7-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE Chemical Properties

• storage temp.: 2-8°C
• form: Solid
• color: Light yellow to yellow
• LogP: 3.247 (est)

3,5-DIHYDROXY-7-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE Usage And Synthesis

Uses

Kaempferol-7,4'-dimethyl ether is a PTP1B inhibitor, and also can inhibit the production of NO. Kaempferol-7,4'-dimethyl ether shows the inhibition rate of 46.1% at 100 μM. Kaempferol-7,4'-dimethyl ether inhibits PTP1B activity with IC50 value of 16.92 μM[1][2].

Definition

ChEBI: 7,4'-dimethylkaempferol is a dimethoxyflavone that is kaempferol in which the hydroxy groups at position 4' and 7 have been replaced by methoxy groups. It is a component of bee glue and has been isolated from several plant species including Betula exilis, Zingiber mekongense and Alpinia flabellata. It has a role as an antioxidant and a plant metabolite. It is a dimethoxyflavone, a dihydroxyflavone and a member of flavonols. It is functionally related to a kaempferol. It is a conjugate acid of a 7,4'-O-dimethylkaempferol 3-olate.

References

[1] Teeratad, et al. Inhibition of nitric oxide production by compounds from Boesenbergia longiflora using lipopolysaccharide-stimulated RAW264.7 macrophage cells.[J]. Songklanakarin Journal of Science & Technology, 2013.
[2] To D-C, et al. PTP1B Inhibitory Flavonoids From Orthosiphon stamineus Benth. and Their Growth Inhibition on Human Breast Cancer Cells. Natural Product Communications. 2020,15(1).