4-AMINO-3-FLUOROBENZOIC ACID CAS 455-87-8
Introduction：Basic information about 4-AMINO-3-FLUOROBENZOIC ACID CAS 455-87-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
4-AMINO-3-FLUOROBENZOIC ACID Basic information
| Product Name: | 4-AMINO-3-FLUOROBENZOIC ACID |
| Synonyms: | 4-amino-3-fluoro-benzoicaci;4-AMINO-3-FLUOROBENZENECARBOXYLIC ACID;4-AMINO-3-FLUOROBENZOIC ACID;BUTTPARK 44\09-60;3-FLUORO-4-AMINOBENZOIC ACID;4-Amino-3-Fluorobenzoic;NSC 25758;4-AMINO-3-FLUOROBENZ |
| CAS: | 455-87-8 |
| MF: | C7H6FNO2 |
| MW: | 155.13 |
| EINECS: | 207-250-1 |
| Product Categories: | Fluorine series;Aromatics;Benzoic acid;Amines;blocks;Carboxes;FluoroCompounds;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Aromatics Compounds |
| Mol File: | 455-87-8.mol |
4-AMINO-3-FLUOROBENZOIC ACID Chemical Properties
| Melting point | 215-218°C |
| Boiling point | 320.8±27.0 °C(Predicted) |
| density | 1.430±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Hot Water |
| pka | 4.52±0.10(Predicted) |
| form | Fine Needles |
| color | White to Light yellow to Light orange |
| InChIKey | JSKXHTHMCCDEGD-UHFFFAOYSA-N |
| CAS DataBase Reference | 455-87-8(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xi |
| RTECS | DG2525000 |
| HazardClass | IRRITANT |
| HS Code | 2922498590 |
| Chemical Properties | Fine Needles |
| Synthesis | 403-21-4 455-87-8 In a 1000 mL round-bottomed single-necked flask, 3-fluoro-4-nitrobenzoic acid (30 g, 190 mmol) was dissolved in 300 mL of a solvent mixture of methanol and tetrahydrofuran, and carbon-loaded palladium (2 g) was added as a catalyst. The reaction system was charged with hydrogen and the reaction was stirred at room temperature for 15 hours. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filtrate was collected. The filtrate was dried to give a white solid product. The white solid was further dried in an oven to finally obtain 3-fluoro-4-aminobenzoic acid (24.86 g, 98.6% yield). |
| References | [1] Patent: CN105294567, 2016, A. Location in patent: Paragraph 0033-0036 [2] Tetrahedron, 2018, vol. 74, # 47, p. 6795 - 6803 [3] Journal of the American Chemical Society, 1944, vol. 66, p. 1631 [4] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 12, p. 2697 - 2706 |
4-AMINO-3-FLUOROBENZOIC ACID Preparation Products And Raw materials
| Raw materials | 3-Fluoro-4-nitrobenzoic acid-->Hydrogen-->Activated carbon-->Tetrahydrofuran-->Palladium-->Methanol |
| Preparation Products | 3-FLUORO-4-IODOBENZOIC ACID-->Methyl-4-amino-3-fluorobenzoate-->(4-AMINO-3-FLUORO-PHENYL)-METHANOL |
