Introduction：Basic information about 4-Amino-5-imidazolecarboxamide hydrochloride CAS 72-40-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
4-Amino-5-imidazolecarboxamide hydrochloride Basic information
| Product Name: | 4-Amino-5-imidazolecarboxamide hydrochloride |
| Synonyms: | 5-amino-4-imidazolecarboxamide hydrochloride (intermediate of dacarbazine);5-Amino-1H-imidazole-4-carboxamide hydrochloride 98%;5-amino-1H-imidazole-4-carboxamide HCl;4-Amino-5-(aminocarbonyl)imidazole Hydrochloride;4-AMINO-5-IMIDAZOLECARBOXAMIDE HCL, (AICA) 98+%;4-AMINO-5-IMIDAZOLECARBOXAMIDE HYDROCHLORIDE 99%;4-Amino-5-imidazolecarboxamide hydrochloride ,99%;4-Amino-5-imidazolecarboxamide hydrochloride,98% |
| CAS: | 72-40-2 |
| MF: | C4H7ClN4O |
| MW: | 162.58 |
| EINECS: | 200-778-3 |
| Product Categories: | Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines;pharmacetical;Imidazoles;(intermediate of dacarbazine) |
| Mol File: | 72-40-2.mol |
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4-Amino-5-imidazolecarboxamide hydrochloride Chemical Properties
| Melting point | 250-252 °C (dec.)(lit.) |
| storage temp. | 2-8°C |
| solubility | water: soluble50mg/mL, clear, light yellow |
| form | Crystals or Crystalline Powder |
| color | White |
| Water Solubility | SOLUBLE |
| Sensitive | Hygroscopic |
| BRN | 3701645 |
| Stability: | Hygroscopic |
| InChI | InChI=1S/C4H6N4O.ClH/c5-3-2(4(6)9)7-1-8-3;/h1H,5H2,(H2,6,9)(H,7,8);1H |
| InChIKey | MXCUYSMIELHIQL-UHFFFAOYSA-N |
| SMILES | C1(N=CNC=1N)C(=O)N.Cl |
| CAS DataBase Reference | 72-40-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Imidazole-4(5)-carboxamide, 5-(4)-amino-, hydrochloride(72-40-2) |
| EPA Substance Registry System | 1H-Imidazole-4-carboxamide, 5-amino-, monohydrochloride (72-40-2) |
Safety Information
| Hazard Codes | Xi,Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 22-24/25-36-26 |
| WGK Germany | 3 |
| RTECS | NI3911000 |
| Hazard Note | Irritant |
| TSCA | TSCA listed |
| HS Code | 29332990 |
| Storage Class | 11 - Combustible Solids |
4-Amino-5-imidazolecarboxamide hydrochloride Usage And Synthesis
| Chemical Properties | very slightly beige fine powder |
| Uses | 5-Amino-4-imidazolecarboxamide hydrochloride was used in the synthesis of heterocyclic compounds such as guanine, purines and pyrimidines.
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| General Description | Corrosion inhibition and adsorption characteristics of 5-amino-4-imidazolecarboxamide hydrochloride on aluminum in 1M HCl has been investigated. |
| Synthesis | 47 g of sodium nitrite was dissolved in 1.2 liters of water; The solution was cooled to 0° C. 100 g of 5-aminoimidazole-4 carboxamide was dissolved in a solution of hydrochloric acid (80 ml of 36% HCL in 720 ml water) with stirring. The resultant 5-aminoimidazole-4 carboxamide hydrochloride solution was added slowly, drop-wise, over 20-30 minutes at 0-5° C. After the addition was completed, the reaction mixture was stirred for 10 minutes and filtered. The solid obtained was suspended in 400 ml DM water and stirred for 15 minutes. The suspension was filtered and suction-dried for 15 minutes. The obtained solid was suspended in 500 ml of THF and stirred for 15 minutes. The suspension was filtered and suction-dried for 15 minutes. Finally, the solid was dried at 45° C. to afford 4-Amino-5-imidazolecarboxamide hydrochloride.
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| Purification Methods | Recrystallise the hydrochloride from EtOH. [Kuroda & Hakko JEst(1) Est(2)Heterocycl Chem 30 593 1993, Alhede et al. J Org Chem 56 2139 1991, Cheru et al. Heterocycles 24 1133 1992, Beilstein 25 II 221, 25 III/IV 4329.] |
4-Amino-5-imidazolecarboxamide hydrochloride Preparation Products And Raw materials
| Raw materials | Acetamide-->carbanilic acid |
| Preparation Products | 5-(Amino-1-(N-methyl Carbamoyl)-->ETHYL 4-AMINO-5-IMIDAZOLECARBOXYLATE |
