Introduction：Basic information about 4-Amino-6-chlorobenzene-1,3-disulfonamide CAS 121-30-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
4-Amino-6-chlorobenzene-1,3-disulfonamide Basic information
| Product Name: | 4-Amino-6-chlorobenzene-1,3-disulfonamide |
| Synonyms: | 4-amino-6-chloro-3-benzenedisulfonamide;5-Chloro-2,4-bis(sulfonamido)aniline;4-AMino-6-chloro-1,3-benzenedisulfonaMide 98%;Benzothiadiazine realted compound A;4-amino-6-chloro-1,3-benzenedisulphonamide;Hydrochlorothiazide EP Impurity B;LABOTEST-BB LT00261357;CHLORAMINOPHENAMIDE |
| CAS: | 121-30-2 |
| MF: | C6H8ClN3O4S2 |
| MW: | 285.73 |
| EINECS: | 204-463-1 |
| Product Categories: | Phenyls & Phenyl-Het;Aromatics;Phenyls & Phenyl-Het;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;121-30-2 |
| Mol File: | 121-30-2.mol |
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4-Amino-6-chlorobenzene-1,3-disulfonamide Chemical Properties
| Melting point | 257-261 °C(lit.) |
| Boiling point | 614.4±65.0 °C(Predicted) |
| density | 1.584 (estimate) |
| refractive index | 1.6100 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 9.24±0.60(Predicted) |
| form | Powder |
| color | White to off-white |
| Merck | 14,2076 |
| BRN | 1083877 |
| InChI | InChI=1S/C6H8ClN3O4S2/c7-3-1-4(8)6(16(10,13)14)2-5(3)15(9,11)12/h1-2H,8H2,(H2,9,11,12)(H2,10,13,14) |
| InChIKey | IHJCXVZDYSXXFT-UHFFFAOYSA-N |
| SMILES | C1(S(N)(=O)=O)=C(Cl)C=C(N)C(S(N)(=O)=O)=C1 |
| CAS DataBase Reference | 121-30-2(CAS DataBase Reference) |
| EPA Substance Registry System | 1,3-Benzenedisulfonamide, 4-amino-6-chloro- (121-30-2) |
Safety Information
| Hazard Codes | T |
| Risk Statements | 23/24-33-20/21 |
| Safety Statements | 28-36/37-36/37/39-26-22 |
| WGK Germany | 3 |
| TSCA | TSCA listed |
| HazardClass | IRRITANT |
| HS Code | 29350090 |
| Storage Class | 11 - Combustible Solids |
4-Amino-6-chlorobenzene-1,3-disulfonamide Usage And Synthesis
| Description | 4-Amino-6-chlorobenzene-1,3-disulfonamide is obtained by treating the chloride with ammonia in tert-butanol and concentrating the solution by evaporation; the yield is 80 %. Condensation with formic acid gives 6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide, an important diuretic. |
| Chemical Properties | Light Brown Solid |
| Uses | Diuretic. |
| Uses | 4-Amino-6-chloro-1,3-benzenedisulfonamide was used in the synthesis of deuterated thiazides by undergoing condensation with appropriately labeled aldehydes. |
| Definition | ChEBI: Chloraminophenamide is a sulfonamide. |
| General Description | Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. |
4-Amino-6-chlorobenzene-1,3-disulfonamide Preparation Products And Raw materials
| Raw materials | 3-Chloroaniline-->Chloramine-T-->4-AMINO-6-CHLORO-BENZENE-1,3-DISULFONYL DICHLORIDE-->Hydrochlorothiazide-->Hydrochlorothiazide Impurity 28-->Hydrochlorothiazide Impurity 4-->Trichlormethiazide |
| Preparation Products | Chlorothiazide-->4-AMINO-5,6-DICHLOROBENZENE-1,3-DISULFONAMIDE-->3-Des(allylthio)Methyl-3-chloroMethyl Althiazide-->EX5004 |
