Introduction：Basic information about 4-Fluorobenzyl chloride CAS 352-11-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
4-Fluorobenzyl chloride Basic information
| Product Name: | 4-Fluorobenzyl chloride |
| Synonyms: | Benzene, 1-(chloromethyl)-4-fluoro-;à-chloro-4-fluorotoluene;4-Fluorobenzyl chloride 99%;p-Fluorbenzylchlorid;4-FLUOROBENZYL CHLORIDE;P-FLUOROBENZYL CHLORIDE;5) PARA FLUORO BENZYL CHLORIDE;α-Chloro-4-fluorotoluene, 1-Chloromethyl-4-fluorobenzene |
| CAS: | 352-11-4 |
| MF: | C7H6ClF |
| MW: | 144.57 |
| EINECS: | 206-516-4 |
| Product Categories: | Fluorine series;bc0001 |
| Mol File: | 352-11-4.mol |
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4-Fluorobenzyl chloride Chemical Properties
| Melting point | -18 °C |
| Boiling point | 82 °C26 mm Hg(lit.) |
| density | 1.207 g/mL at 25 °C(lit.) |
| refractive index | n20/D 1.513(lit.) |
| Fp | 141 °F |
| storage temp. | Store below +30°C. |
| solubility | Chloroform (Slightly), Hexanes (Slightly) |
| form | Powder or Crystals |
| Specific Gravity | 1.207 |
| color | Yellow |
| explosive limit | 1.30%(V) |
| Water Solubility | 417mg/L(temperature not stated) |
| Sensitive | Lachrymatory |
| BRN | 742272 |
| InChI | 1S/C7H6ClF/c8-5-6-1-3-7(9)4-2-6/h1-4H,5H2 |
| InChIKey | IZXWCDITFDNEBY-UHFFFAOYSA-N |
| SMILES | Fc1ccc(CCl)cc1 |
| CAS DataBase Reference | 352-11-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzene, 1-(chloromethyl)-4-fluoro-(352-11-4) |
| EPA Substance Registry System | Benzene, 1-(chloromethyl)-4-fluoro- (352-11-4) |
Safety Information
| Hazard Codes | C |
| Risk Statements | 34-22 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 2920 8/PG 2 |
| WGK Germany | 2 |
| F | 19 |
| Hazard Note | Corrosive/Lachrymatory |
| TSCA | TSCA listed |
| HazardClass | 8 |
| PackingGroup | III |
| HS Code | 29036990 |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| Hazard Classifications | Skin Corr. 1B |
4-Fluorobenzyl chloride Usage And Synthesis
| Chemical Properties | clear colorless to slightly yellow liquid |
| Uses | p-Fluorobenzyl Chloride is a chemical intermediate in the synthesis of various pharmaceutical and agricultural goods. |
| Synthesis | Photocatalyst: nanosilver/silver chloride surface plasma composite;
Substrate: p-fluorotoluene; Halogenator: potassium chloride;
(1) 50 ml of water, 7 g of sodium chloride and 2.5 ml of hydrochloric acid (mass fraction 35%) were added in a photocatalytic reactor, respectively, and dissolved with stirring;
(2) then add 0.3 g of nanosilver/silver chloride as a photocatalyst (nanosilver loading 8.5 mol%) and 0.05 g of tetrabutylammonium chloride as a phase-transfer catalyst, and finally add 15 ml of p-fluorotoluene; the loading is the molar amount of nanoprecious metals as a molar percentage of the total amount of nanoprecious metal/semiconductor surface plasmonic composite.
(3) Under strong magnetic stirring, then turn on 300W xenon lamp irradiation, and react for 5h at room temperature;
(4) Filtering to recover the catalyst, separating out the organic phase and recycling the aqueous phase for reuse. Samples were analyzed by GS, the conversion rate of p-fluorotoluene was 36%, and no polychlorinated products were detected. Distillation to collect 180.5-182 ?? fraction, got 4-fluorobenzyl chloride, yield 89%. |
4-Fluorobenzyl chloride Preparation Products And Raw materials
| Raw materials | Benzene, 1,1'-[oxybis(methylene)]bis[4-fluoro--->3,5-DICHLORO-2,4,6-TRIFLUOROBENZOIC ACID |
| Preparation Products | 3-(4-FLUOROPHENYL)PROPIONIC ACID-->2-FLUORO-6-METHYLNAPHTHALENE-->1-(4-FLUOROBENZYL)-1,4-DIAZEPANE-->4-(4-FLUOROBENZYLOXY)BENZALDEHYDE-->L-4-Fluorophenylalanine-->alpha-Chloro-o-fluorotoluene-->1-(4-Fluorophenyl)-2-methylpropan-2-amine-->(4-FLUORO-BENZYL)-METHYL-AMINE-->1-[(4-fluorophenyl)methyl]imidazole-->Benzenepropanal, 4-fluoro-α,α-dimethyl--->1-(4-fluorobenzyl)piperidin-3-ol |
