Introduction：Basic information about 5-Amino-4-imidazolecarboxamide CAS 360-97-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
5-Amino-4-imidazolecarboxamide Basic informationDescription Reference
| Product Name: | 5-Amino-4-imidazolecarboxamide |
| Synonyms: | 4-AMINOIMIDAZOLE-5-CARBOXAMIDE;4-amino-5-imidazolecarboxamid;5-amino-1h-imidazole-4-carboxamid;5-Amino-4-glyoxalinecarboxamide;5-amino-imidazole-4-carboxamid;5-amino-4-imidazolecarboxamide;5-AMINOIMIDAZOLE-4-CARBOXAMIDE;5-AMINO-1H-IMIDAZOLE-4-CARBOXAMIDE |
| CAS: | 360-97-4 |
| MF: | C4H6N4O |
| MW: | 126.12 |
| EINECS: | 206-641-4 |
| Product Categories: | Amines;Amines, Metabolites & Impurities, Nucleotides, Bases & Related Reagents;Building Blocks;Heterocyclic Building Blocks;Imidazoles;pharmacetical;Imidazol&Benzimidazole;Various Metabolites and Impurities;Bases & Related Reagents;Metabolites & Impurities;Nucleotides;bc0001 |
| Mol File: | 360-97-4.mol |
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5-Amino-4-imidazolecarboxamide Chemical Properties
| Melting point | 164-170 °C(lit.) |
| Boiling point | 234.22°C (rough estimate) |
| density | 1.3659 (rough estimate) |
| refractive index | 1.8500 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| pka | 11.97±0.10(Predicted) |
| form | Powder |
| color | White |
| Water Solubility | Soluble in DMSO, Methanol, Water. |
| InChI | InChI=1S/C4H6N4O/c5-3-2(4(6)9)7-1-8-3/h1H,5H2,(H2,6,9)(H,7,8) |
| InChIKey | DVNYTAVYBRSTGK-UHFFFAOYSA-N |
| SMILES | C1NC(N)=C(C(N)=O)N=1 |
| CAS DataBase Reference | 360-97-4(CAS DataBase Reference) |
| EPA Substance Registry System | 1H-Imidazole-4-carboxamide, 5-amino- (360-97-4) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | UN2811 |
| WGK Germany | 3 |
| RTECS | NI3910000 |
| TSCA | TSCA listed |
| HazardClass | 6.1 |
| HS Code | 29332900 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
5-Amino-4-imidazolecarboxamide Usage And Synthesis
| Description | 5-Amino-4-imidazolecarboxamide may be used in the synthesis of 4-(N′-benzoylcarbamoyl)amino-5-imidazolecarboxamide and 5-amino-1-β-D-ribosyl-4-imidazolecarboxamide-5′-phosphate (AICAR).It is an imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a condensation agent in the preparation of nucleosides and nucleotides. When compounded with orotic acid, it is used to treat liver diseases. |
| Reference | 3. Black, S. L., M. J. Black, and J. H. Mangum. "A rapid assay for 5-amino-4-imidazolecarboxamide ribotide transformylase." Analytical Biochemistry90.1(1978):397-401. |
| Chemical Properties | White to Off-White Solid |
| Uses | A metabolite of Temozolomide |
| Uses | 4-Aminoimidazole-5-carboxamide is used as Catalytic agent, Petrochemical additive. It is metabolite of temozolomide. |
| Uses | 5-Amino-4-imidazolecarboxamide may be used in the synthesis of 4-(N′-benzoylcarbamoyl)amino-5-imidazolecarboxamide and 5-amino-1-β-D-ribosyl-4-imidazolecarboxamide-5′-phosphate (AICAR). |
| Definition | ChEBI: An aminoimidazole in which the amino group is at C-5 with a carboxamido group at C-4. |
5-Amino-4-imidazolecarboxamide Preparation Products And Raw materials
| Raw materials | Glycinamide |
| Preparation Products | Temozolomide-->Dacarbazine-->5-(Amino-1-(N-methyl Carbamoyl)-->ETHYL 4-AMINO-5-IMIDAZOLECARBOXYLATE-->Temozolomide Impurity |
