Introduction：Basic information about 5-Fluoro-2-oxindole CAS 56341-41-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
5-Fluoro-2-oxindole Basic information
| Product Name: | 5-Fluoro-2-oxindole |
| Synonyms: | 5-Fluoroindole-2-One;5-Fluoro-1,3-dihydro-indol-2-one;5-FLUORO-2-OXINDOLE;5-FLUORO-2-OXYINDOLE;5-FLUORO-1,3-DIHYDRO-2H-INDOL-2-ONE;5-Fluorooxindole 98%;5-Fluorooxindole98%;5-FLUROOXINDOLE |
| CAS: | 56341-41-4 |
| MF: | C8H6FNO |
| MW: | 151.14 |
| EINECS: | 638-803-9 |
| Product Categories: | Fluorinated heterocyclic series;Indoles and derivatives;Indole/indoline/oxindole;Indole and Indoline;Heterocycles;Aromatics Compounds;Halides;Pyrroles & Indoles;ketone;Sunitinib;Aromatics;Intermediate of sunitinib malate;Pyrroles & Indoles;Boronic Acid;Heterocyclic Compounds;Building Blocks;Heterocyclic Building Blocks;Indoles;INDOLE;blocks;FluoroCompounds;IndolesOxindoles;Intermediates;56341-41-4 |
| Mol File: | 56341-41-4.mol |
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5-Fluoro-2-oxindole Chemical Properties
| Melting point | 143-147 °C (lit.) |
| Boiling point | 307.2±42.0 °C(Predicted) |
| density | 1.311±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Powder or Crystalline Powder |
| pka | 12.99±0.20(Predicted) |
| color | White to pale brown |
| InChI | InChI=1S/C8H6FNO/c9-6-1-2-7-5(3-6)4-8(11)10-7/h1-3H,4H2,(H,10,11) |
| InChIKey | DDIIYGHHUMKDGI-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=C(F)C=C2)CC1=O |
| CAS DataBase Reference | 56341-41-4(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xi,C |
| Risk Statements | 36/37/38-34 |
| Safety Statements | 22-24/25-45-36/37/39-27-26 |
| WGK Germany | 3 |
| Hazard Note | Irritant/Keep Cold |
| HazardClass | IRRITANT, KEEP COLD |
| HS Code | 29339900 |
| Storage Class | 13 - Non Combustible Solids |
5-Fluoro-2-oxindole Usage And Synthesis
| Chemical Properties | Light Yellow Crystalline |
| Uses | 5-Fluoro-2-oxindole (cas# 56341-41-4) is a compound useful in organic synthesis. |
| Application | 5-Fluoro-2-oxindole is a ketone organic compound that can be used as an intermediate in the preparation of sunitinib. Sunitinib is a novel multi-targeted oral drug for the treatment of tumors. |
| Preparation | synthesis of 5-fluoro-2-oxindole: 4-fluoroaniline was used as the starting material, reacted with chloral hydrate and hydroxylamine hydrochloride to generate 4-fluoroisonitrosoacetanilide, and then cyclized under the action of concentrated sulfuric acid to form the compound 5-fluoroisatin was finally obtained by wolff-kishner-huang minlon reduction to obtain 5-fluoro-2-oxindole with a total yield of 66%. |
| Biological Activity | 5-Fluoro-2-oxindole has anti-inflammatory, antioxidant, anxiolytic, antidepressant and antinociceptive effects and inhibits neuropathic pain. Treatment with 5-Fluoro-2-oxindole increased the expression of NQO1, HO-1, and MOR in the spinal cord and/or paw and inhibited CFA-induced up-regulation of phosphorylated MAPK, 4-HNE, NOS2, CD11b/c, and IBA-1. 5-Fluoro-2-oxindole ameliorated the local effects of morphine. Studies have revealed that 5-fluoro-2-oxindole inhibits plasticity, oxidative and inflammatory responses induced by peripheral inflammation and enhances the antinociceptive effects of morphine. Thus, the use of 5-fluoro-2-indole alone and/or in combination with morphine are two remarkable new approaches for the treatment of chronic inflammatory pain. |
5-Fluoro-2-oxindole Preparation Products And Raw materials
| Raw materials | Sodium hydride-->Iron-->Dimethyl sulfoxide-->Dimethyl malonate-->Lithium chloride-->2,4-Difluoronitrobenzene-->1-hydroxy-3H-indol-2-one-->Ethyl iodoacetate-->4-FLUOROISONITROSOACETANILIDE-->5-Fluoro-3-hydrazonoindolin-2-one-->2-(2-aMino-5-fluorophenyl)acetohydrazide-->5-Fluoro-2-nitrophenylacetic acid-->Benzeneacetic acid, 5-fluoro-2-nitro-, Methyl ester-->5-Fluoroisatin-->4-Fluoroacetanilide-->ETHYL (METHYLTHIO)ACETATE-->tert-Butyl Hypochlorite |
| Preparation Products | Toceranib |
