5-Hydroxy-3',4',7-trimethoxyflavone CAS 29080-58-8

Introduction：Basic information about 5-Hydroxy-3',4',7-trimethoxyflavone CAS 29080-58-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

5-Hydroxy-3',4',7-trimethoxyflavone Basic information

• Product Name: 5-Hydroxy-3',4',7-trimethoxyflavone
• Synonyms: 4H-1-Benzopyran-4-one, 2-(3,4-diMethoxyphenyl)-5-hydroxy-7-Methoxy-;Gonzalitosin I;Luteolin 7,3',4'-trimethyl ether;2-(3,4-DiMethoxyphenyl)-5-hydroxy-7-Methoxy-4H-chroMen-4-one;7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone);2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one;Rutoside Trihydrate Impurity 12;COX,TNFR,7,3',4'TriOmethylluteolin,lipopolysaccharide,Tumor Necrosis Factor Receptor,Inflammation-related diseases,pro-inflammatory cytokines,RAW 264.7 macrophage,Interleukin Related,inhibit,TNF Receptor,Cyclooxygenase,7,3',4' Tri O methylluteolin,Inhibitor
• CAS: 29080-58-8
• MF: C18H16O6
• MW: 328.32
• Mol File: 29080-58-8.mol

5-Hydroxy-3',4',7-trimethoxyflavone Chemical Properties

• Melting point: 163 °C
• Boiling point: 536.3±50.0 °C(Predicted)
• density: 1.314±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: Soluble in DMSO
• pka: 6.32±0.40(Predicted)
• form: Solid
• color: White to yellow

5-Hydroxy-3',4',7-trimethoxyflavone Usage And Synthesis

Uses

7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone), a flavonoid compound, possesses potent anti-inflammatory effects in LPS-induced macrophage cell line mediated by inhibition of release of inflammatory mediators, NO, PGE2, and pro-inflammatory cytokines. 7,3',4'-Tri-O-methylluteolin significantly induces reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2[1].

IC 50

IL-6; IL-1β; COX-2

References

[1] Sudha, A, et al. Protective effect of 5-hydroxy-3′,4′,7-trimethoxyflavone against inflammation induced by lipopolysaccharide in RAW 264.7 macrophage: in vitro study and in silico validation. Medicinal Chemistry Research, 2016,25(9), 1754–1767.