Introduction：Basic information about 6-HYDROXY-7-METHOXYCOUMARIN CAS 776-86-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
6-HYDROXY-7-METHOXYCOUMARIN Basic information
| Product Name: | 6-HYDROXY-7-METHOXYCOUMARIN |
| Synonyms: | 7-METHOXY-6-HYDROXYCOUMARIN;6-HYDROXY-7-METHYLCOUMARIN;6-HYDROXY-7-METHOXYCOUMARIN;ISOSCOPOLETIN;ISOSCOPOLETINE;6-hydroxy-7-methoxy-2-benzopyrone;6-Hydroxy-7-methyl coumarin-(Isoscopoletin) -;ISOSCOPOLETIN (6-HYDROXY-7-METHYLCOUMARIN) |
| CAS: | 776-86-3 |
| MF: | C10H8O4 |
| MW: | 192.17 |
| EINECS: | 212-282-4 |
| Product Categories: | reagent;standard substance;Coumarins |
| Mol File: | 776-86-3.mol |
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6-HYDROXY-7-METHOXYCOUMARIN Chemical Properties
| Melting point | 206-208°C |
| Boiling point | 413.5±45.0 °C(Predicted) |
| density | 1.37 g/cm3 |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO: soluble |
| form | Solid |
| pka | 8.94±0.20(Predicted) |
| color | Pale Beige to Light Beige |
| InChI | 1S/C10H8O4/c1-13-9-5-8-6(4-7(9)11)2-3-10(12)14-8/h2-5,11H,1H3 |
| InChIKey | SYTYLPHCLSSCOJ-UHFFFAOYSA-N |
| SMILES | COc1cc2OC(=O)C=Cc2cc1O |
| LogP | 0.830 (est) |
| CAS DataBase Reference | 776-86-3 |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 22-24/25-36-26 |
| WGK Germany | 3 |
| F | 8 |
| HS Code | 29322090 |
| Storage Class | 11 - Combustible Solids |
6-HYDROXY-7-METHOXYCOUMARIN Usage And Synthesis
| Description | Isoscopolamine is an antiasthmatic drug, which has the effect of relaxing smooth muscle and antihistamine. It can be used clinically in patients with chronic bronchitis and bronchial asthma. |
| Chemical Properties | Yellow needle-like crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from Dengzhanhua, Rhododendron. |
| Uses | Isoscopolamine has anti-inflammatory, antioxidant, improving myocardial ischemia, anti-arrhythmic effects. |
| Definition | ChEBI: Isoscopoletin is a hydroxycoumarin that is esculetin in which the hydroxy group at position 7 is replaced by a methoxy group. It is the major primary metabolite of scoparone. It has a role as a plant metabolite. It is a hydroxycoumarin and an aromatic ether. It is functionally related to an esculetin. |
| Biological Activity | Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active ingredient in Artemisia argyi. It has a significant inhibitory effect on cell proliferation with IC50 values of 4.0 μM and 1.6 μM against human CCRF-CEM leukemia cells and drug-resistant subline CEM/ADR5000, respectively. It (6-Hydroxy-7-methoxycoumarin) has the activity of inhibiting HBV replication. |
6-HYDROXY-7-METHOXYCOUMARIN Preparation Products And Raw materials
| Raw materials | Ethyl acetate-->PETROLEUM ETHER-->Acetic anhydride-->Sodium acetate trihydrate-->Ammonium persulfate-->Isovanillin |
